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標題: Expression of 53BP1 as a cisplatin-resistant marker in patients with lung adenocarcinomas
作者: Lai, T.C.
Chow, K.C.
Lin, T.Y.
Chiang, I.P.
Fang, H.Y.
Chen, C.Y.
Ho, S.P.
關鍵字: 53BP1;DNA repair;cisplatin resistance;lung adenocarcinoma;cigarette;smoking;interstrand cross-link;dna-damage;cancer cells;repair;p53;checkpoint;acetaldehyde;instability;progression;induction
Project: Oncology Reports
期刊/報告no:: Oncology Reports, Volume 24, Issue 2, Page(s) 321-328.
DNA repair is one of the major causes of spontaneous drug and radiation resistance in patients with lung adenocarcinomas (LADC). 53BP1 is a mediator that relays signals from DNA damage sensors and activates various effectors for the DNA repair and cell survival. In this study we investigated the clinical and biological significance of 53BP1. Expression of 53BP1 was detected by immunoblotting and immunohistochemistry. Our data showed that 53BP1 was detected in 166 (75.8%) of 219 LADC patients. Expression of 53BP1 correlated with tumor stage, cigarette smoking, lymphovascular invasion and poor clinical outcome. In vitro, increased 53BP1 expression elevated drug resistance, and silencing of 53BP1 expression reduced cisplatin resistance. Our results suggest that 53BP1 expression plays an important role in cisplatin resistance and predicts the prognosis for LADC.
ISSN: 1021-335X
DOI: 10.3892/or_00000862
Appears in Collections:生物醫學研究所

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