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標題: Expression profiling of human epidermal keratinocyte response following 1-minute JP-8 exposure
作者: Chou, C.C.
Yang, J.H.
Chen, S.D.
Monteiro-Riviere, N.A.
Li, H.N.
Chen, J.J.W.
關鍵字: cDNA microarray;gene expression;jet fuel;keratinocyte;jet fuel exposure;lung epithelial-cells;gene-expression;interleukin-8;release;dermal exposure;toxicity;skin;differentiation;identification;cytotoxicity
Project: Cutaneous and Ocular Toxicology
期刊/報告no:: Cutaneous and Ocular Toxicology, Volume 25, Issue 2, Page(s) 141-153.
The cDNA microarray analysis of 9600 expressed sequence tags was performed to examine the gene expression changes in human epidermal keratinocytes after 1-minute JP-8 exposure, 151 genes were identified as JP-8 responsive and classified into 8 clusters by self organization map. Genes involved in basal transcription and translations were up-regulated, whereas genes related to DNA repair, metabolism, and keratin were mostly down-regulated. Genes encoded for growth factors, apoptosis, signal transduction, and adhesion were also altered. These results indicated that human keratinocyte responds to a single dose of JP-8 insult and revealed several cellular processes previously not associated with jet fuel exposure.
ISSN: 1556-9527
DOI: 10.1080/15569520600695728
Appears in Collections:生物醫學研究所

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