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標題: Synthesis and characterization of pH-sensitive dextran hydrogels as a potential colon-specific drug delivery system
作者: Chiu, H.C.
Hsiue, G.H.
Lee, Y.P.
Huang, L.W.
關鍵字: dextran hydrogels;pH-dependent swelling;biodegradable hydrogels;colonic drug delivery;poly(ethylene glycol);controlled-release;in-vitro;degradation;polymers;behavior;proteins;network
Project: Journal of Biomaterials Science-Polymer Edition
期刊/報告no:: Journal of Biomaterials Science-Polymer Edition, Volume 10, Issue 5, Page(s) 591-608.
pH-Sensitive dextran hydrogels were prepared by activation of dextran (T-70) with 4-nitrophenyl chloroformate, followed by conjugation of the activated dextran with 4-aminobutyric acid and cross-linking with 1,10-diaminodecane. The cross-linking efficiencies determined by mechanical measurements were in the range of 52-63%. Incorporation of carboxylpropyl groups in dextran hydrogels led to a higher equilibrium and faster swelling under high pH conditions. The swelling reversibility of hydrogels was also observed after repeated changes in buffers between pH 2.0 and 7.4. The slow rates of swelling and deswelling in response to changes in pH were attributed to the hydrophilic nature of dextran and formation of hydrogen bonds between the hydroxyl groups of dextran with water molecules. The pronounced effect of carboxylic acid content on degradation of hydrogels was observed after 4 h of incubation with dextranase and the influence significantly decreased after exposure to the enzyme for 8 h. The mechanism of bulk degradation of hydrogels under high swelling extent was substantiated using Coomassie blue protein assay. The release rate of bovine serum albumin from hydrogrels was primarily determined by the swelling extent. The release rate was further enhanced by addition of dextranase in buffer solutions.
ISSN: 0920-5063
DOI: 10.1163/156856299x00504
Appears in Collections:化學工程學系所

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