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|標題:||Synthesis of pH-sensitive inulin hydrogels and characterization of their swelling properties||作者:||Chiu, H.C.
|關鍵字:||inulin hydrogels;pH-dependent swelling;crosslinking density;acrylic;acid;dextran hydrogels;glycidyl methacrylate;drug-delivery;polymerization;carriers;gels||Project:||Journal of Biomedical Materials Research||期刊/報告no：:||Journal of Biomedical Materials Research, Volume 61, Issue 1, Page(s) 146-152.||摘要:||
In this study, pH-responsive inulin hydrogels were prepared by radical copolymerization of methacrylated inulin (MA-inulin) with acrylic acid (AAc) in aqueous solution using ammonium peroxydisulfate (APS) and N,N,N',N'-tetramethylethylenediamine (TMEDA) as an initiation system. The AAc content in hydrogels was evaluated by FTIR spectroscopy. The covalent bridging of AAc among MA moieties of MA-inulins was observed by a significant increase in the effective network density of hydrogels and further confirmed by TGA studies. While, at a low content of AAc, the hydration of hydrogels at pH 7.4 decreased owing to the increased crosslinking density, the swelling subsequently increased with further increasing AAc as a consequence of the increased ionic osmotic pressure within hydrogels. The change in swelling of hydrogels in response to pH change between 7.4 and 2.2 was therefore enlarged when the AAc content increased. (C) 2002 Wiley Periodicals, Inc.
|Appears in Collections:||化學工程學系所|
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