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標題: Synthesis and characterization of acrylic acid-containing dextran hydrogels
作者: Chiu, H.C.
Wu, A.T.
Lin, Y.F.
關鍵字: dextran hydrogels;pH-dependent swelling;enzymatic degradability;ph-sensitive hydrogels;controlled-release;enzymatic degradation;glycidyl methacrylate;drug-delivery;poly(ethylene glycol);model;protein;cross-linking;in-vitro;microspheres
Project: Polymer
期刊/報告no:: Polymer, Volume 42, Issue 4, Page(s) 1471-1479.
pH-Sensitive dextran hydrogels were prepared by free radical polymerization of methacrylate derivatized dextran, acrylic acid and N-t-butylacrylamide. Incorporation of acrylic acid in hydrogels was confirmed by Fourier transform infrared spectroscopy. The pH-dependent swelling of hydrogels was strongly influenced by the acrylic acid content, conjugation degree of methacrylate moiety with dextran and modified dextran concentration. Intermolecular polymerization that occurred to a greater extent with a lower degree of conjugation of methacrylate and/or higher concentration of modified dextran effectively increased the network density of hydrogels. An increase of acrylic acid reduced the enzymatic degradability of pre-swollen hydrogels by dextranase, although the increased equilibrium swelling was observed. (C) 2000 Elsevier Science Ltd. All rights reserved.
ISSN: 0032-3861
DOI: 10.1016/s0032-3861(00)00523-1
Appears in Collections:化學工程學系所

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