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標題: Biocompatibility and biostability of a series of poly(carbonate)urethanes
作者: Hsu, S.H.
Lin, Z.C.
關鍵字: biocompatibility;biostability;micro-phase separation;poly(carbonate)urethane;protein adsorption;blood compatibility;protein adsorption;polyurethanes;surface;adhesion;segment
Project: Colloids and Surfaces B-Biointerfaces
期刊/報告no:: Colloids and Surfaces B-Biointerfaces, Volume 36, Issue 1, Page(s) 1-12.
In this work. we synthesized several NIDI-based poly(carbonate)urethanes (PCU) by using four different soft segments, including two aliphatic macrodiols (poly(hexyl, ethyl)carbonate diols, MW 2017 and 865, respectively) and two aromatic macrodiols (MW similar to 2000 and 1000, respectively), in different molar ratios to MDI. We demonstrate that these polymers exhibited various degree of micro-phase separation that further influenced their surface protein adsorption, platelet activation as well as cellular attachment and growth. Polyurethanes based on poly(hexyl, ethyl)carbonate diol with MW 2017 in a molar ratio MDI/macrodiol/chain extender of either 3/2/1 or 4/3/1 resulted in greater micro-phase separation as well as superior biocompatibility and biostability. (C) 2004 Elsevier B.V. All rights reserved.
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2004.04.003
Appears in Collections:化學工程學系所

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