Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/41374
DC FieldValueLanguage
dc.contributor.authorChen, C.J.en_US
dc.contributor.author徐善慧zh_TW
dc.contributor.authorOu, Y.C.en_US
dc.contributor.authorLiao, S.L.en_US
dc.contributor.authorChen, W.Y.en_US
dc.contributor.authorChen, S.Y.en_US
dc.contributor.authorWu, C.W.en_US
dc.contributor.authorWang, C.C.en_US
dc.contributor.authorWang, W.Y.en_US
dc.contributor.authorHuang, Y.S.en_US
dc.contributor.authorHsu, S.H.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-06T08:05:26Z-
dc.date.available2014-06-06T08:05:26Z-
dc.identifier.issn0014-4886zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/41374-
dc.description.abstractCell transplantation using bone marrow stromal cells (BMSCs) to alleviate neurological deficits has recently become the focus of research in regenerative medicine. Evidence suggests that secretion of various growth-promoting substances likely plays an important role in functional recovery against neurological diseases. In an attempt to identify a possible mechanism underlying the regenerative potential of BMSCs, this study investigated the production and possible contribution of neurotrophic factors by transected sciatic nerve defect in a rat model with a 15 mm gap. Cultured BMSCs became morphologically homogeneous with fibroblast-like shape after ex vivo expansion. We provided several pieces of evidence for the beneficial effects of implanted fibroblast-like BMSCs on sciatic nerve regeneration. When compared to silicone tube control animals, this treatment led to (i) improved walking behavior as measured by footprint analysis, (ii) reduced loss of gastrocnemius muscle weight and EMG magnitude, and (iii) greater number of regenerating axons within the tube. Cultured fibroblast-like BMSCs constitutively expressed trophic factors and supporting substances, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), collagen, fibronectin, and laminin. The progression of the regenerative process after BMSC implantation was accompanied by elevated expression of neurotrophic factors at both early and later phases. These results taken together, in addition to documented Schwann cell-like differentiation, provide evidence indicating the strong association of neurotrophic factor production and the regenerative potential of implanted BMSCs. (c) 2006 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationExperimental Neurologyen_US
dc.relation.ispartofseriesExperimental Neurology, Volume 204, Issue 1, Page(s) 443-453.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.expneurol.2006.12.004en_US
dc.subjectbone marrow stromal cellsen_US
dc.subjectneurotrophic factoren_US
dc.subjectregenerationen_US
dc.subjectsciaticen_US
dc.subjectnerveen_US
dc.subjectSchwann cellsen_US
dc.subjecttransplantationen_US
dc.subjectmesenchymal stem-cellsen_US
dc.subjectschwann-cellsen_US
dc.subjectadult ratsen_US
dc.subjectin-vitroen_US
dc.subjectaxonalen_US
dc.subjectregenerationen_US
dc.subjectprogenitor cellsen_US
dc.subjectsciatic-nervesen_US
dc.subjectbrainen_US
dc.subjectproteinen_US
dc.subjectdifferentiateen_US
dc.titleTransplantation of bone marrow stromal cells for peripheral nerve repairen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.expneurol.2006.12.004zh_TW
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:化學工程學系所
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