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標題: A novel use of genipin-fixed gelatin as extracellular matrix for peripheral nerve regeneration
作者: Liu, B.S.
Yao, C.H.
Hsu, S.H.
Yeh, T.S.
Chen, Y.S.
Kao, S.T.
關鍵字: gelatin;genipin;peripheral nerve regeneration;cross-linking;sciatic-nerve;schwann-cells;in-vitro;silicone tubes;collagen;laminin;fibronectin;chambers;bioadhesives
Project: Journal of Biomaterials Applications
期刊/報告no:: Journal of Biomaterials Applications, Volume 19, Issue 1, Page(s) 21-34.
Application of combining herbal medicine and biomedical material science to nerve regeneration is a new approach. In this study, we describe a novel use of purified genipin, which can be extracted from Gardenia jasminoides Ellis, fixing the gelatin to be an extracellular matrix for peripheral nerve regeneration. A 10-mm gap of rat sciatic nerve was created between the proximal and distal nerve stumps, which were sutured into silicone rubber tubes filled with either the genipin-fixed gelatin or collagen gel. Silicone rubber tubes filled with saline were used as controls. Six weeks after implantation, regeneration across the nerve gaps occurred in 80 and 90% of the animals from the groups of genipin-fixed gelatin and collagen, respectively, whereas only 30% in them control group. Large numbers of myelinated axons were also seen in the genipin-fixed gelatin (5104 +/- 3278) and the collagen groups (8063 +/- 1807). These findings indicated that the genipin-fixed gelatin could be an acceptable extracellular matrix for nerve regeneration.
ISSN: 0885-3282
DOI: 10.1177/0885328204042544
Appears in Collections:化學工程學系所

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