Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/41383
DC FieldValueLanguage
dc.contributor.authorLiu, B.S.en_US
dc.contributor.author徐善慧zh_TW
dc.contributor.authorYao, C.H.en_US
dc.contributor.authorHsu, S.H.en_US
dc.contributor.authorYeh, T.S.en_US
dc.contributor.authorChen, Y.S.en_US
dc.contributor.authorKao, S.T.en_US
dc.date2004zh_TW
dc.date.accessioned2014-06-06T08:05:27Z-
dc.date.available2014-06-06T08:05:27Z-
dc.identifier.issn0885-3282zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/41383-
dc.description.abstractApplication of combining herbal medicine and biomedical material science to nerve regeneration is a new approach. In this study, we describe a novel use of purified genipin, which can be extracted from Gardenia jasminoides Ellis, fixing the gelatin to be an extracellular matrix for peripheral nerve regeneration. A 10-mm gap of rat sciatic nerve was created between the proximal and distal nerve stumps, which were sutured into silicone rubber tubes filled with either the genipin-fixed gelatin or collagen gel. Silicone rubber tubes filled with saline were used as controls. Six weeks after implantation, regeneration across the nerve gaps occurred in 80 and 90% of the animals from the groups of genipin-fixed gelatin and collagen, respectively, whereas only 30% in them control group. Large numbers of myelinated axons were also seen in the genipin-fixed gelatin (5104 +/- 3278) and the collagen groups (8063 +/- 1807). These findings indicated that the genipin-fixed gelatin could be an acceptable extracellular matrix for nerve regeneration.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Biomaterials Applicationsen_US
dc.relation.ispartofseriesJournal of Biomaterials Applications, Volume 19, Issue 1, Page(s) 21-34.en_US
dc.relation.urihttp://dx.doi.org/10.1177/0885328204042544en_US
dc.subjectgelatinen_US
dc.subjectgenipinen_US
dc.subjectperipheral nerve regenerationen_US
dc.subjectcross-linkingen_US
dc.subjectsciatic-nerveen_US
dc.subjectschwann-cellsen_US
dc.subjectin-vitroen_US
dc.subjectsilicone tubesen_US
dc.subjectcollagenen_US
dc.subjectlamininen_US
dc.subjectfibronectinen_US
dc.subjectchambersen_US
dc.subjectbioadhesivesen_US
dc.titleA novel use of genipin-fixed gelatin as extracellular matrix for peripheral nerve regenerationen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1177/0885328204042544zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
Appears in Collections:化學工程學系所
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