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標題: Preparation of networks of gelatin and genipin as degradable biomaterials
作者: Yao, C.H.
Liu, B.S.
Chang, C.J.
Hsu, S.H.
Chen, Y.S.
關鍵字: gelatin;genipin;cross-linking;biomaterials;cross-linking reagent;biological tissue fixation;in-vitro evaluation;blue pigments;agent;cytotoxicity;methylamine
Project: Materials Chemistry and Physics
期刊/報告no:: Materials Chemistry and Physics, Volume 83, Issue 2-3, Page(s) 204-208.
The aim of this study is to prepare networks of Bloom number 300 gelatin and genipin as degradable biomaterials. The cross-linking ability of genipin on gelatin was studied and discs were made from the genipin-fixed gelatin. The swelling ratio, the degree of cross-linking, and the rate of degradation of the discs were measured using ninhydrin assay and differential scanning calorimetry (DSC) experiments. The results indicated that genipin is a good cross-linker for the gelatin. Additionally, varying the concentration of genipin can control the rate of degradation and the degree of cross-linking of the genipin-fixed gelatin. Finally, the concentration of genipin should exceed 0.5% of the overall weight of the gelatin-based material if a complete cross-linking reaction between gelatin and genipin molecules is required. (C) 2003 Elsevier B.V. All rights reserved.
ISSN: 0254-0584
DOI: 10.1016/j.mathchemphys.2003.08.027
Appears in Collections:化學工程學系所

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