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標題: (-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant
作者: Wang, H.M.
Chen, C.Y.
Ho, M.L.
Chou, Y.T.
Chang, H.C.
Lee, C.H.
Wang, C.Z.
Chu, I.M.
關鍵字: (-)-N-Formylanonaine;Tyrosinase inhibitor;Melanocyte;Molecular;docking;human epidermal melanocytes;keratinocyte-derived factors;chemical-constituents;pigmentation;tea;melanogenesis;dendricity;melanoma;extract;growth
Project: Bioorganic & Medicinal Chemistry
期刊/報告no:: Bioorganic & Medicinal Chemistry, Volume 18, Issue 14, Page(s) 5241-5247.
Tyrosinase is the first and rate limiting enzyme in the synthesis of melanin pigments for coloring hair, skin, and eyes. As reported in this study, a natural product, (-)-N-formylanonaine isolated from the leaves of Michelia alba D. C. (Magnolianceae), was found to inhibit mushroom tyrosinase with an IC(50) of 74.3 mu M and to have tyrosinase and melanin reducing activities in human epidermal melanocytes without apparent cytotoxicity to human cells, superior to the known tyrosinase inhibitors, such as kojic acid and 1-phenyl-2-thiourea (PTU). Based on homology modeling, the compound binds the active site by coordinating with two Cu(2+) ions. In addition, the compound had antioxidation activities in tests for scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH), reducing power, and chelating metal ions. To our knowledge, this is the first study to reveal the bioactivities of (-)-N-formylanonaine from this plant species. (C) 2010 Elsevier Ltd. All rights reserved.
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2010.05.045
Appears in Collections:化學工程學系所

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