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|標題:||(-)-N-Formylanonaine from Michelia alba as a human tyrosinase inhibitor and antioxidant||作者:||Wang, H.M.
|關鍵字:||(-)-N-Formylanonaine;Tyrosinase inhibitor;Melanocyte;Molecular;docking;human epidermal melanocytes;keratinocyte-derived factors;chemical-constituents;pigmentation;tea;melanogenesis;dendricity;melanoma;extract;growth||Project:||Bioorganic & Medicinal Chemistry||期刊/報告no：:||Bioorganic & Medicinal Chemistry, Volume 18, Issue 14, Page(s) 5241-5247.||摘要:||
Tyrosinase is the first and rate limiting enzyme in the synthesis of melanin pigments for coloring hair, skin, and eyes. As reported in this study, a natural product, (-)-N-formylanonaine isolated from the leaves of Michelia alba D. C. (Magnolianceae), was found to inhibit mushroom tyrosinase with an IC(50) of 74.3 mu M and to have tyrosinase and melanin reducing activities in human epidermal melanocytes without apparent cytotoxicity to human cells, superior to the known tyrosinase inhibitors, such as kojic acid and 1-phenyl-2-thiourea (PTU). Based on homology modeling, the compound binds the active site by coordinating with two Cu(2+) ions. In addition, the compound had antioxidation activities in tests for scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH), reducing power, and chelating metal ions. To our knowledge, this is the first study to reveal the bioactivities of (-)-N-formylanonaine from this plant species. (C) 2010 Elsevier Ltd. All rights reserved.
|Appears in Collections:||化學工程學系所|
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