Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/41972
標題: A NON-ACYL AZIDE ROUTE TO ISOQUINOLIN-1(2H)-ONE DERIVATIVES VIA beta-STYRIL CARBAMATES
作者: Chen, C.C.
戴憲弘
Chen, L.Y.
Lin, R.Y.
Chu, C.Y.
Dai, S.A.
關鍵字: Isoquinolin-1(2H)-one;beta-Styril Carbamate;Phenylacetaldehyde;Enol;Ether of Benzyl Ketone;Non-Chlorine Route;ring expansion;rearrangement;isocyanates;isocarbostyrils;epoxides;aldehydes;ketones;esters;acids
Project: Heterocycles
期刊/報告no:: Heterocycles, Volume 78, Issue 12, Page(s) 2979-2992.
摘要: 
The efficient reactions of the phenyl acetaldehydes la-e and the enol ethers of benzyl ketones 1o-s with ethyl urethane lead to the formation of the beta-styril carbamates 2, which are excellent precursors for generating isoquinolin-1(2H)-ones 4. Upon thermolysis at 230 degrees C in an inert organic solution, the carbamates decomposed into the transient beta-styril isocyanate intermediates 3. The resulting isoquinolin-1(2H)-ones obtained were in good yields (65-93%). This synthetic methodology allows the convenient preparation of isoquinolin-1 (2H)-ones via a non-phosgene and non-acyl azide route from readily accessible starting materials.
URI: http://hdl.handle.net/11455/41972
ISSN: 0385-5414
DOI: 10.3987/com-09-11800
Appears in Collections:化學工程學系所

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