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標題: Fabrication of PLGA microvessel scaffolds with circular microchannels using soft lithography
作者: Wang, G.J.
Hsueh, C.C.
Hsu, S.H.
Hung, H.S.
關鍵字: capillary-electrophoresis;devices;design
Project: Journal of Micromechanics and Microengineering
期刊/報告no:: Journal of Micromechanics and Microengineering, Volume 17, Issue 10, Page(s) 2000-2005.
A simple micromolding method for fabricating PLGA ( poly( lactic-co-glycolic acid)) microstructures made up of microchannels with a circular cross-section is presented. The thermal reflow technique is adopted to fabricate the semi-cylindrical photoresist master. The PLGA solution is prepared by dissolving PLGA polymer in acetone and then casting the solution onto the semi-cylindrical photoresist master to produce PLGA microstructures. Two PLGA membranes are bonded together to form microstructures consisting of circular microchannels. A microvessel scaffold suitable for tissue engineering was fabricated using the proposed method, and bovine endothelial cells were cultured into the scaffold by semi-dynamic seeding. The cell stain Calcein-AM was used to overcome the problem of the PLGA scaffolds becoming opaque, which in the past had made it difficult to effectively monitor the progress of cell seeding.
ISSN: 0960-1317
DOI: 10.1088/0960-1317/17/10/011
Appears in Collections:化學工程學系所

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