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標題: Bio-MEMS fabricated artificial capillaries for tissue engineering
作者: Wang, G.J.
Chen, C.L.
Hsu, S.H.
Chiang, Y.L.
關鍵字: microfabrication;electrophoresis;design
Project: Microsystem Technologies-Micro-and Nanosystems-Information Storage and Processing Systems
期刊/報告no:: Microsystem Technologies-Micro-and Nanosystems-Information Storage and Processing Systems, Volume 12, Issue 1-2, Page(s) 120-127.
In this report, we focus on the microfabrication and cell seeding issues of artificial blood capillaries for tissue engineering. Two different fabrication methods (stainless steel electroforming and silicon electroforming) and a number of materials (PC, Polycarbonate and biocompatible material PLGA, poly lactide-co-glycolides) are implemented to build the vascular network. The vascular network is then used as the scaffold to cultivate the bovine endothelial cell (BEC). During the period of cell cultivation, oxygen and nutrient need to be continuously delivered by a circular pressurizing system. In cell culture, encouraging results are obtained through the dynamical seeding of the BEC on the scaffolds. A systematic cell culture process has been developed after repeated experiments. Successful seeding efficiencies are obtained by using the developed systematic cell culture process.
ISSN: 0946-7076
DOI: 10.1007/s00542-005-0017-7
Appears in Collections:化學工程學系所

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