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標題: Antimicrobial Activities and Cellular Responses to Natural Silicate Clays and Derivatives Modified by Cationic Alkylamine Salts
作者: Hsu, S.H.
Tseng, H.J.
Hung, H.S.
Wang, M.C.
Hung, C.H.
Li, P.R.
Lin, J.J.
關鍵字: montmorillonite;mica;silicate platelet;cytotoxicity;extracellular-signal-regulated kmase (ERK);controlled-release;gene-expression;smectite clays;montmorillonite;migration;cells;intercalation;exfoliation;platelets;adhesion
Project: Acs Applied Materials & Interfaces
期刊/報告no:: Acs Applied Materials & Interfaces, Volume 1, Issue 11, Page(s) 2556-2564.
Nanometer-scale silicate platelet (NSP) materials were previously developed by-increasing the interlayer space and exfoliadon of layered silicate clays such as montmorillonite and synthetic fluorinated mica by the process of polyamine exfoliation. In this study, the antibacterial activity and cytotoxicity of these nanometer-scale silicate clays were evaluated. The derivatives of NSP (NSP-S) which were modified by C18-fatty amine salts via ionic exchange association exhibited the highest antibacterial activity in the aqueous state among all clays. The high antibacterial activity, however, was accompanied by elevated cytoroxicity. The variations of cell surface markers (CD29 and CD44) and type l collagen expression of fibroblasts treated with the clays were measured to clarify the mechanism of the silicate-induced cytotoxicity. The signal transduction pathway involved the downregulation of extracellular signal-regulated kinase (ERK), which appeared to participate in silicate-induced cytotoxicity. This study helped to understand the antibacterial potential of NSP and the interaction of natural and modified clays with cellular, activities.
ISSN: 1944-8244
DOI: 10.1021/am900479q
Appears in Collections:材料科學與工程學系

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