Please use this identifier to cite or link to this item:
標題: Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats
作者: Tsai, M.H.
Huang, G.S.
Hung, Y.C.
Bin, L.
Liao, L.T.
Lin, L.W.
關鍵字: Psoralea corylifolia;ovariectomized;osteoporosis;replacement therapy;bone metabolism;estrogen;density;guidelines;women;age
Project: American Journal of Chinese Medicine
期刊/報告no:: American Journal of Chinese Medicine, Volume 35, Issue 4, Page(s) 669-680.
We evaluated the protective effect of Psoralea corylifolia L. (PCL) extract on the ovariectomized (OVX) rat model. The biochemical markers of bone turnover, calcium metabolism, and calcium balance were examined. PCL extract (25 mg or 50 mg/kg body weight/day) was orally administrated to OVX rats for 3 months. PCL extract did not alter weight gain or uterus weight in OVX rats. PCL extract significantly increased serum Ca (calcium) levels (p < 0.05, vs. OVX group) as well as decreased urinary Ca excretion (p < 0.05, vs. OVX group) in OVX rats. The upregulation of serum osteocalcin level by ovariectomy was suppressed by treatment with PCL extract in rats (p < 0.05, vs. OVX group). PCL extract increased bone mineral density at 50 mg/kg body weight/day in OVX rats (p < 0.05, vs. OVX group). Our results indicate that orally administrated PCL extract can decrease urinary calcium excretion and decrease serum osteocalcin in OVX rats, resulting in positive effects on bone mineral density as well as bone formation. In conclusion, our studies showed that PCL might be a potential candidate for treatment of postmenopausal osteoporosis.
ISSN: 0192-415X
DOI: 10.1142/s0192415x07005168
Appears in Collections:資訊管理學系

Show full item record

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.