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標題: Vancomycin–chitosan composite deposited on post porous hydroxyapatite coated Ti6Al4V implant for drug controlled release
作者: Yang, Chi-Chuan
Lin, Chien-Chung
Liao, Jiunn-Wang
Yen, Shiow-Kang
關鍵字: Vancomycin–chitosan composite;Post porous hydroxyapatite coated Ti4Al4V;Osteomyelitis
Project: Materials Science and Engineering: C, Volume 33, Issue 4, Page(s) 2203–2212.
Through the hydrogen bonds and the deprotonation, the vancomycin–chitosan composite has been originally
deposited on Ti4Al4V by electrochemical technology. However, the rapid destruction of the hydrogen bonding
between them by polar water molecules during immersion tests revealed 80% drug burst in a few hours.
In this study, the post porous hydroxyapatite (HA) coated Ti4Al4V is prepared for the subsequent electrolytic
deposition of vancomycin–chitosan composite to control the drug release. As expected, the initial burst is reduced
to 55%, followed by a steady release about 20% from day 1 to day 5 and a slower release of the retained
25% after day 6, resulting in bacterial inhibition zone diameter of 30 mm which can last for more than a
month in antibacterial tests, compared with the coated specimen without HA gradually loosing inhibition
zone after 21 days. Besides, the cell culture indicates that the vancomycin–chitosan/HA composite coated
has enhanced the proliferation, the differentiation and the mineralization of the osteoblast-like cell. In general,
it is helpful for the osteointegration on permanent implants. Consistently, it effectively provides the prophylaxis
and therapy of osteomyelitis according to the results of the rabbit infection animal model.
ISSN: 0928-4931
DOI: 10.1016/j.msec.2013.01.038
Appears in Collections:材料科學與工程學系

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