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標題: Attenuating development of cardiovascular hypertrophy with hydrolysate of chicken leg bone protein in spontaneously hypertensive rats
作者: Cheng, F.Y.
Wan, T.C.
Liu, Y.T.
Lai, K.M.
Lin, L.C.
Sakata, R.
關鍵字: angiotensin I converting enzyme (ACE);chicken leg bone protein;hydrolysate;antihypertensive effect;cardiovascular hypertrophy;angiotensin-converting enzyme;long-term intake;inhibitory peptides;heart-rate;blood-pressure;risk factor;myosin;purification;captopril;disease
Project: Asian-Australasian Journal of Animal Sciences
期刊/報告no:: Asian-Australasian Journal of Animal Sciences, Volume 21, Issue 5, Page(s) 732-737.
This study developed a natural ingredient as a functional food possessing properties of attenuation of hypertension and cardiovascular hypertrophy. In a previous study hydrolysates obtained from chicken leg bone protein using Alcalase strongly inhibited angiotensin I converting enzyme (ACE) in vitro. In particular, hydrolysate (A4H) from four hours of incubation exhibited the highest ACE inhibitory activity (IC50=0.545 mg/ml). A4H was selected as a potent ACE inhibitor and orally administrated to spontaneously hypertensive rats (SHR) for eight weeks to investigate attenuating effects on age-related development of hypertension and cardiovascular hypertrophy. Results showed that treatment with A4H of SHRs attenuated the development of hypertension as effectively as the clinical antihypertensive drug captopril. Moreover, a significantly lower heart to body weight ratio and thinness of coronary arterial wall was observed in SHRs that had been treated with A4H or captopril. The results suggest that A4H can be utilized in developing an ACE inhibitor as a potential ingredient of functional foods to alleviate hypertension and cardiovascular hypertrophy.
ISSN: 1011-2367
Appears in Collections:動物科學系

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