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標題: Characterization of metabolic activation of pentachlorophenol to quinones and semiquinones in rodent liver
作者: Tsai, C.H.
Lin, P.H.
Waidyanatha, S.
Rappaport, S.M.
關鍵字: pentachlorophenol;protein adduct;quinone;semiquinone;dna-damage;organochlorine pesticides;chlorinated quinone;lipid-peroxidation;hydrogen-peroxide;human-fibroblasts;covalent;binding;protein adducts;b6c3f1 mice;tetrachlorohydroquinone
Project: Chemico-Biological Interactions
期刊/報告no:: Chemico-Biological Interactions, Volume 134, Issue 1, Page(s) 55-71.
Pentachlorophenol (PCP), a widely used biocide, induces liver tumors in mice but not in rats. Metabolic activation of PCP to chlorinated quinones and semiquinones in liver cytosol from Spraque-Dawley rats and B6C3F1 mice was investigated in vitro(1) with microsomes in the presence of either beta -nicotinamide adenine dinucleotide phosphate (NADPH) or cumene hydroperoxide (CHP): (2) with CK in the absence of microsomes, and (3) with horseradish peroxidase (HRP) and H(2)O(2). Mono-S- and multi-S-substituted adducts of tetrachloro-1,4-benzoquinone (Cl(4)-1,4-BQ) and Cl(4)-1,2-BQ and their corresponding semiquinones [i.e. tetrachloro-1,4-benzosemiquinone (Cl(4)-1,4-SQ) and tetrachloro-1:2-benzosemiquinone (Cl(4)-1,2-SQ)] were measured by gas chromatography-mass spectrometry (CrC-MS). Qualitatively, the metabolites of PCP were the same in both rats and mice for all activation systems. Induction of PCP metabolism by either 3MC or PB-treated microsomes
ISSN: 0009-2797
DOI: 10.1016/s0009-2797(00)00318-5
Appears in Collections:環境工程學系所

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