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標題: A novel guanylyl cyclase receptor, BdmGC-1, is highly expressed during the development of the oriental fruit fly Bactrocera dorsalis (Hendel)
作者: Chang, J.C.
Yang, R.B.
Chen, Y.H.
Lu, K.H.
關鍵字: cGMP;guanylyl cyclase;receptor;glycoprotein;Bactrocera dorsalis;natriuretic-peptide receptor;manduca-sexta;nitric-oxide;eclosion;hormone;cyclic-gmp;sensory neurons;nervous-system;alpha-subunit;beta-subunit;identification
Project: Insect Molecular Biology
期刊/報告no:: Insect Molecular Biology, Volume 15, Issue 1, Page(s) 69-77.
A novel receptor guanylyl cyclase (GC) has been identified from the oriental fruit fly Bactrocera dorsalis (Hendel) and has been designated BdmGC-1. Protein domain analysis revealed that BdmGC-1 possesses a characteristic domain organization similar to all known receptor GCs but with a unique carboxyl-terminal extension. When overexpressed in 293T cells, BdmGC-1 manifests as a cell-surface glycoprotein with a marked cGMP-generating activity but is unresponsive to all ligands known to activate mammalian receptor GCs. BdmGC-1 mRNAs were highly expressed during development but had low or no expression in adult tissues. On the basis of its unique sequence and distinct developmental expression pattern, BdmGC-1 represents a novel receptor GC that may play a critical role during the development of B. dorsalis.
ISSN: 0962-1075
DOI: 10.1111/j.1365-2583.2006.00609.x
Appears in Collections:昆蟲學系

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