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標題: Isolation and Identification of Secondary Metabolites of Clitocybe nuda Responsible for Inhibition of Zoospore Germination of Phytophthora capsici
作者: Chen, Jin-Tong
Su, Huey-Jen
Huang, Jenn-Wen
關鍵字: Clitocybe nuda;secondary metabolite;antifungal substance;Phytophthora capsici;indole-3-carbaldehyde;p-benzoquinone
Project: J. Agric. Food Chem.,Volume 60, Page(s) 7341−7344.
Secondary metabolites of Clitocybe nuda displayed antimicrobial activity against Phytophthora capsici. The culture
filtrate of C. nuda was extracted with ethanol and chromatographically separated on a Sephadex LH-20 column and fractionated
on a silica gel column to give eight fractions. These fractions were tested for the ability to inhibit zoospore germination of P.
capsici. The most active fraction was further purified by silica gel column chromatography to yield three compounds: 2-methoxy-
5-methyl-6-methoxymethyl-p-benzoquinone (1), 6-hydroxy-2H-pyran-3-carbaldehyde (2), and indole-3-carbaldehyde (3), all
new to C. nuda. At a concentration of 500 mg/L, compound 3 showed complete inhibition of zoospore germination, while
compounds 1 and 2 showed inhibition rates of 97 and 86%, respectively. To our knowledge, compound 1 is a newly discovered
compound and, for the other two compounds, this is the first report in C. nuda. These compounds are potential candidates for
new edible fungi-derived pesticides for the control of plant diseases.
DOI: 10.1021/jf301570y
Appears in Collections:植物病理學系

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