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標題: Dead volume free micro-machined electro-spray chip for mass spectrometry
作者: Wang, G.J.
Yang, M.W.
Chang, Y.Z.
關鍵字: mass spectrometry electro-spray chip;precise mechanical micro;machining;Taylor cone;microfabricated devices
Project: Biomedical Microdevices
期刊/報告no:: Biomedical Microdevices, Volume 6, Issue 2, Page(s) 159-164.
Design and fabrication themes of a dead volume free electro-spray chip for mass spectrometry based on mechanical micro-machining approach is discussed in this article. To implement the dead volume free concept, a cantilever needle is embedded inside the micro-channel of the spray-chip such that there is no connecting joint between the sample wall and the spray-tip. To ensure that the proposed spray-chip is able to produce efficient Taylor cone, embedded needles with different cone angles are fabricated to produce an efficient experiment. Experiments to distinguish amphetamine by a LCQ type mass spectrometry are conducted. Experimental results show that the proposed dead volume free electro-spray chip is able to reach the desired goal. It is also found from the experiments that the ringlike cross-section of the needle embedded micro-channel is critical to the stability of the Taylor cone at the spray-tip. To ensure a stable Taylor cone can be produced at the spray-tip, an embedded needle with a smaller diameter is desired.
ISSN: 1387-2176
DOI: 10.1023/B:BMMD.0000031754.40550.c0
Appears in Collections:生醫工程研究所

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