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標題: | A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development | 作者: | He, X.J. 王國祥 Hsu, Y.F. Zhu, S.H. Liu, H.L. Pontes, O. Zhu, J.H. Cui, X.P. Wang, C.S. Zhu, J.K. |
關鍵字: | RDM4;siRNA;transcriptional gene silencing;Pol II;Pol V;polymerase-ii;arabidopsis-thaliana;pol-iv;protein;glycosylase/lyase;pathways;subunit;ros1 | Project: | Genes & Development | 期刊/報告no:: | Genes & Development, Volume 23, Issue 23, Page(s) 2717-2722. | 摘要: | RNA-directed DNA methylation (RdDM) is a conserved mechanism for epigenetic silencing of transposons and other repetitive elements. We report that the rdm4 (RNA-directed DNA Methylation4) mutation not only impairs RdDM, but also causes pleiotropic developmental defects in Arabidopsis. Both RNA polymerase II (Pol II)- and Pol V-dependent transcripts are affected in the rdm4 mutant. RDM4 encodes a novel protein that is conserved from yeast to humans and interacts with Pol II and Pol V in plants. Our results suggest that RDM4 functions in epigenetic regulation and plant development by serving as a transcriptional regulator for RNA Pol V and Pol II, respectively. |
URI: | http://hdl.handle.net/11455/50306 | ISSN: | 0890-9369 | DOI: | 10.1101/gad.1851809 |
Appears in Collections: | 生物科技學研究所 |
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