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標題: A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development
作者: He, X.J.
Hsu, Y.F.
Zhu, S.H.
Liu, H.L.
Pontes, O.
Zhu, J.H.
Cui, X.P.
Wang, C.S.
Zhu, J.K.
關鍵字: RDM4;siRNA;transcriptional gene silencing;Pol II;Pol V;polymerase-ii;arabidopsis-thaliana;pol-iv;protein;glycosylase/lyase;pathways;subunit;ros1
Project: Genes & Development
期刊/報告no:: Genes & Development, Volume 23, Issue 23, Page(s) 2717-2722.
RNA-directed DNA methylation (RdDM) is a conserved mechanism for epigenetic silencing of transposons and other repetitive elements. We report that the rdm4 (RNA-directed DNA Methylation4) mutation not only impairs RdDM, but also causes pleiotropic developmental defects in Arabidopsis. Both RNA polymerase II (Pol II)- and Pol V-dependent transcripts are affected in the rdm4 mutant. RDM4 encodes a novel protein that is conserved from yeast to humans and interacts with Pol II and Pol V in plants. Our results suggest that RDM4 functions in epigenetic regulation and plant development by serving as a transcriptional regulator for RNA Pol V and Pol II, respectively.
ISSN: 0890-9369
DOI: 10.1101/gad.1851809
Appears in Collections:生物科技學研究所

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