Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/5156
DC FieldValueLanguage
dc.contributor王應然zh_TW
dc.contributor洪俊雄zh_TW
dc.contributor.advisor林伯雄zh_TW
dc.contributor.author施聖彰zh_TW
dc.contributor.authorShih, Sheng-Changen_US
dc.contributor.other中興大學zh_TW
dc.date2007zh_TW
dc.date.accessioned2014-06-06T06:34:10Z-
dc.date.available2014-06-06T06:34:10Z-
dc.identifierU0005-1408200623360500zh_TW
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dc.identifier.urihttp://hdl.handle.net/11455/5156-
dc.description.abstract本研究運用活體外(in vitro)生物檢測之細胞增生分析法(Cell Proliferation Assay,CPA)之中,以人類乳癌細胞增生分析法(Estrogen-screen assay)評估化學物質之雌性激素各種干擾效應,檢驗微生物分解對環境雌性激素物質的干擾效應,包括酚甲烷(bisphenol-A,BPA) 雌性激素促進效應、加保利(carbaryl)之雌性激素促進及抑制效應之影響。 本研究中以人類乳癌細胞增生分析法之實驗結果確認: 1.酚甲烷具有雌性激素促進效應,而為雌性激素干擾效應之促進物質。在濃度範圍(10-5M~10-8M)內,E-screen與酵母菌雌性激素篩選法(yeast estrogen screen, YES)結果相當一致。 2.加保利在濃度範圍(10-8M~10-6M)時有約二倍的E2促進效應,在高濃度(10-4M)以上時有細胞毒性導致較低E2促進效應(0.26、0.03<2.40),在較低濃度範圍(10-12M~10-9M)內為具雌性激素抑制物質。 3.酚甲烷細菌分解液在低濃度範圍(10-5M~10-8M)時有較高E2促進效應,在高濃度範圍(>10-5M)未見到有細胞毒性,而在濃度範圍(1.~2.*10-5M)內,E-screen與YES結果相當接近。 4.固相萃取之酚甲烷細菌分解液在濃度範圍內,有較低之E2促進效應,但趨勢相符,在低濃度範圍(10-8M~10-9M)內,E-screen與YES結果不同。 5.加保利細菌分解液細胞抑制效應在實驗濃度範圍內,從整體看時有較弱的E2抑制效應,可看出E-screen與YES結果趨勢相同,數值結果較為不同。 本研究結果證實,微生物分解對不同種類之雌性激素干擾物質之降解作用應個別逐一篩檢。E-screen與YES測試結果雖有差異但大體而言相當一致。 因此運用微生物分解作為生物處理方法,分解具環境荷爾蒙效應之有機污染物,其成效之評估有必要進一步研究及釐清。zh_TW
dc.description.abstractThe primary purpose of this study is to apply the Estrogen screening assay (E-screen) to evaluate the effects of microbial degradation on the (anti)estrogenic effects of environmental estrogens, including bisphenol-A and carbaryl. Results from the E-screen analyses indicated that: 1. Bisphenol-A is a potent estrogenic chemical at concentrations ranging from 10-5M~10-8M. Results from the E-screen analyses are comparable with those reported by the yeast estrogen screen (YES) assay. 2. Carbaryl alone displayed estogenic effects at concentrations ranging from 10-8M to 10-6M whereas at concentrations 10-4M of above cytotoxic response was detected. Co-treatment of carbaryl (10-12M~10-9M) the estrogenic effects of endogenous estrogen was inhibited. This evidence suggests that carbaryl possesses both estrogenic and anti-estrogenic effects as assayed by E-screen. 3. The medium derived from microbial degradation of BSA possess estrogenic effects at concentrations ranging from10-5M to10-8M. Results from the E-screen analyses are comparable with those reported by the yeast estrogen screen (YES) assay (1.~2*10-5M). 4. The extracts derived from microbial degradation of BSA after solid phase extraction displayed estrogenic effects at high concentrations ranging from 10-5M to 10-8M. 5. The extracts from the microbial degradation of carbaryl displayed persistant anti-estrogenic effects. Overall, results from our investigation suggest that the impact of microbial degradation processes on the activity of environmental estrogens should be carefully examined and should not be considered solely as a detoxification processes. In general, the experiment results of E-screen and YES are comparable although with some differences. So, the effects of using microbes as the method for microbial degradation to degrade the organic pollutant with Enviromental Hormones effects need further study and distinction.en_US
dc.description.tableofcontents中 文 摘 要 I 英 文 摘 要 II 縮 寫 表 III 目 錄 V 圖 目 錄 VIII 表 目 錄 X 第一章 前 言 1 (一)、研究緣起 1 (二)、研究目的 2 第二章 文獻回顧 5 (一)、環境荷爾蒙 5 1.環境荷爾蒙之興起 5 2.環境荷爾蒙之作用機制 8 3.環境荷爾蒙之篩檢試驗法之介紹 9 4.雌性激素作用 12 5.環境荷爾蒙未來的影響及趨勢 16 6.台灣地區環境中常見環境荷爾蒙 18 7.環境荷爾蒙的人口威脅 19 (二)、人類乳癌 19 1.雌性激素是乳線癌的主要致癌物 21 2.值得注意的男性乳癌 21 3.婦女症後群 22 (三)、酚甲烷(bisphenol-A,BPA) 23 1.酚甲烷簡介 23 2.酚甲烷之雌性激素效應 27 3.酚甲烷分子生物學作用機制 28 4.酚甲烷於魚類飼養之環境水體濃度 28 5.普通人群血清酚甲烷濃度測定 28 6.酚甲烷暴露之母體、胎兒血漿及胎盤中酚甲烷濃度測定 28 7.環境中酚甲烷的降解及去除 29 8.環境的綠色凈化(酚甲烷去除) 31 9.二十個酚甲烷衍生物激素測試 31 10.酚甲烷雄性激素測試 33 (四)、加保利(Carbaryl) 33 1.加保利(甲萘威、西維因、賽文sevin)之簡介 34 2.加保利相關毒理資料 34 3.加保利引進台灣及環境毒理研究 35 4.加保利農藥有效成份檢驗方法 35 5.加保利之法規資料 36 6.加保利之農藥混合協同作用 37 7.加保利作用(掠食者的存在壓力使蛙類死於殺蟲劑) 37 第三章 材料與方法 39 (一)、實驗材料:人類乳癌細胞增生分析法(E-screen assay) 39 1.無菌去離子水(dd H2O) 39 2.化學藥品及配製 39 3.細胞株來源 41 4.實驗設備 41 5.實驗樣本 41 (二)、實驗方法 43 1.細菌分解液之前處理及液相層析儀(HPLC)分析簡介 43 2.細菌分解液之固相萃取法(solid phase extraction,SPE)簡介 43 3.細菌分解液之氣相層析質譜(GC-MS)分析簡介 44 4.酵母菌雌性激素測試法(Yeast Estrogen Screen,YES) 44 5.人類乳癌細胞(T-47D)增生分析法(E-screen assay) 46 第四章 結果與討論 59 (一)、實驗結果 59 1.雌二醇(E2)標準品雌性激素促進效應 59 2.酚甲烷、酚甲烷加雌二醇等標準品雌性激素促進效應 60 3.加保利、加保利加雌二醇等標準品雌性激素促進效應 62 4.酚甲烷細菌分解液雌性激素促進效應 65 5.固相萃取之酚甲烷細菌分解液雌性激素促進效應 68 6.加保利細菌分解液細胞抑制效應 71 (二)、實驗討論 74 1.酚甲烷標準品雌性激素促進效應 74 2.加保利標準品雌性激素促進效應 75 3.酚甲烷細菌分解液雌性激素促進效應 76 4.固相萃取之酚甲烷細菌分解液細胞增生效應 77 5.加保利細菌分解液細胞抑制效應 78 6.實驗方法之比較 79 第五章 結論與建議 80 (一)、結論 80 (二)、建議 82 1.環境荷爾蒙亟需系統化思考和長期關注,有行動就能改善 82 2.環境荷爾蒙國內法規公告列管及執行 82 3.國內「環境荷爾蒙」未來管制及執行重點 82 4.水源保護 83 參考書目 84 一、中文部份 84 (一)圖書 84 (二)期刊論文 84 (三)網路資源 85 二、西文部份 88 (一)Books 88 (二)Journal Articles 88 (三)Electronic Resources 91zh_TW
dc.language.isoen_USzh_TW
dc.publisher環境工程學系所zh_TW
dc.relation.urihttp://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1408200623360500en_US
dc.subjectE-Screenen_US
dc.subject微生物分解zh_TW
dc.subjectmicrobial degradationen_US
dc.subjectestrogensen_US
dc.subject(anti)estrogenicityen_US
dc.subject雌性激素zh_TW
dc.subject干擾效應zh_TW
dc.title以人類乳癌細胞研究微生物分解對環境雌性激素干擾效應之影響zh_TW
dc.titleInvestigation of the effects of microbial degradation on the (anti)estrogenicity of environmental estrogens in human breast cancer cellsen_US
dc.typeThesis and Dissertationzh_TW
item.fulltextno fulltext-
item.languageiso639-1en_US-
item.openairetypeThesis and Dissertation-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
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