Please use this identifier to cite or link to this item:
|標題:||Plasma Homocysteine、Folate and Oxygen-radical are related to Glycosylated hemoglobin in patients with Type 2 Diabetes Mellitus
chen, yu chu
|關鍵字:||反應蛋白C;糖化血色素;丙二醛;總抗氧化力;總同半胱胺酸;自由態同半胱胺酸;CRP;C-reactive protein;HbA1c;Glycosylated hemoglobin;MDA (malondialdehyde);ORAC;Oxygen radical absorbance capacity;tHcy：total Homocysteine;fHcy：free homocysteine 自由態同半胱胺酸||出版社:||食品科學系||摘要:||
Objectives: Diabetes, which has become an epidemic in the 21st century, is known to have high mortality rate and can lead to various chronic diseases. In addition to elevated oxidative stress, diabetics may also have higher plasma homomcysteine (Hcy) levels, but the evidence is inconsistent. Because both oxidative stress and Hcy are possible risk factors of atherosclerotic vascular diseases, we determined the relationships of oxidative stress and Hcy with glycated hemoglobin (HbA1c) in the diabetics. In addition, we determined plasma total Hcy (tHcy) and free Hcy (fHcy) because fHcy has been shown to be a more sensitive marker for ischemic stroke and cardiovascular disease.
Methods and design: We conducted a cross-sectional observation study by measuring plasma levels of HbA1c, Hcy, malodiadehyde (MDA, a marker of lipid peroxidation) and C-reactive protein (CRP, a marker of inflammation) in 136 Type2 diabetics (mean age 63.8) recruited from Taichung area in comparison with 110 healthy controls (mean age 60.1) from the same area. In addition, we measured plasma total antioxidant activity (oxygen-radical absorbance capacity, ORAC), which has not been studied in diabetes.
Results: The diabetics had significantly higher plasma levels of fHcy (P<0.050) and MDA (P<0.001) but had significantly lower values of ORAC (P<0.0001) than the healthy controls. However, the tHcy level was not significantly different. When all subjects were combined (136 diabetics plus 110 controls), we observed significantly positive correlations for HbA1c vs. fHcy (r＝0.20;P<0.05) and HbA1c vs. CRP (r＝0.23;P<0.001) but a negative correlation for HbA1c vs. ORAC (r＝－0.48;P<0.0001). Logistic regression analysis showed that age, diabetes and HbA1C affected ORAC concentration. As the age increased by 1 year, the odds ratio of ORAC greater than 1.5 units was 0.94 times that of ORAC smaller than 1.5 units.(P＝0.012).In addition , As the HbA1C increased,by 1﹪the odds ratio of ORAC greater than 1.5 units was 0.61 times that of ORAC smaller than 1.5 units.(P＝0.0003).It means the higher the age and HbA1c, the lower ORAC.
Conclusions: The present study demonstrates that fHcy is a more sensitive marker than tHcy for diabetes. The diabetics have increased oxidative stress, as indicated by elevated HbA1c levels and lowered ORAC value in the plasma. The combination of elevated fHcy and oxidative stress in the diabetics may predispose the patients to various vascular diseases.The results suggest that the diabetics' patients should consume more antioxidate food to elevate plasma ORAC.
結論: 本研究結果顯示, 對糖尿病人來說自由態同半胱胺酸較總同半胱胺酸具預警性的參考指標，而糖尿病患較非糖尿病者的總抗氧化力較低，且糖尿病患若血糖控制不好糖化血色素升高，會降低總抗氧化力，根據此一結果，糖尿病患宜多攝取抗氧化性食物以提升總抗氧化力。
|Appears in Collections:||食品暨應用生物科技學系|
Show full item record
TAIR Related Article
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.