1. NCHU Institution Repository
  2. 農業暨自然資源學院
  3. 食品暨應用生物科技學系
Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/52009
標題: Immunomodulatory effect of Bifidobacterium logum subsp. infantis GB-1496 in mite allergen-sensitized murine model
Bifidobacterium logum subsp. infantis GB-1496在塵蟎致敏小鼠模式中調節過敏之作用
作者: Huang, Szu-Chi
黃思齊
關鍵字: Bifidobacterium;塵蟎過敏;Der p;allergy
出版社: 食品暨應用生物科技學系所
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摘要: 
Over the years, lactic acid bacteria have long been regarded as the effectiveness of probiotics, which can maintain of intestinal microflora, reduce lactose intolerance, blood pressure, blood fats, anti-cancer, anti-inflammation and regulate the immune system. It is kind of functional food is widely liked by people. Bifidobacterium, is belong to lacitic acid bacteria family and the greatest microflora in the infant gut. In the studies found that the population of Bifidobacterium in the gut is associated with the life span of the host, and the more longevity, the higher proportion of this bacteria.The main function of Bifidobacterium is to treat diarrhea, maintain intestinal microbial homeostasis and protect against harmful intestinal bacteria colonizing. Although there have confirmed their effectiveness in the immune experiments , but generally found that their ability to regulate immunity is not particularly powerful.The previous experiments has been shown that Bifidobacterium longum supsp. infants. GB-1496 had best capacity to modulate immunity in vitro. Therefore, further investigations on regulation of immune responses in murine model in vivo. In the present studies, we fed the Der p-sensitized BALB/c mice on high (3.0*107 cfu/per mice) , medium (9*107 cfu/per mice) and low (3.0*106 cfu/per mice) dose. The proliferation of splenocyte, cytokines secreted by splenocyte (IFN-γ, IL-4, IL-10 and IL-17) , and specific immunoglobulin in serum were measured. The results showed that only medium dose group stimulated by ConA had significant enhance proliferation of splenocyte; high and mediumn dose group can significantly increase the production of IFN-γ, reduced the secretion of IL-4 and no effect of IL-10 and IL-17; IFN-γ/IL-4 ratio is also significantly improved, so that the immune response directed Th1; specific immunoglobulin trial, three doses were significantly lower specific IgE, and High dose can down regular specific IgG1. These results showed that Bifidobacterium longum subsp. infants GB-1640. had ability to modulate in mite allergen-sensitize mice.

多年來，乳酸菌早已被視為擁有多種功效之益生菌，其中主要有維持腸道菌相、降低乳糖不耐症、降血壓、降血脂、抗癌、抗發炎及調節免疫力等，是廣受人們喜愛的保健食品。比菲德氏菌為乳酸菌家族之一，為剛出生之幼兒腸道中的最大菌群，在各項研究中發現，其在腸道中的菌量與人們壽命成正比的關係，越長壽者，其比菲德氏菌比例越高。比菲德氏菌作為益生菌，主要功能在於治療腹瀉、維持腸道菌相和對抗有害菌等。在免疫方面雖已有實驗證實其功效，但普遍研究發現其調節免疫之能力並不特別彰顯，故本實驗目的為選用已在體外試驗中，篩出調節免疫能力較佳之比菲德氏菌，進一步以動物試驗測試其在體內之反應，以開發有強力調節免疫能力之菌株。本實驗是探討以高、中、低三種劑量之比菲德氏菌，餵食Der p致敏之BALB/c小鼠，對脾臟細胞之增生、分泌之細胞激素以及血清中特異性免疫球蛋白含量之影響。結果發現，只有以ConA刺激之Medium dose組的脾臟細胞有顯著性的增生；High及Mediumn dose組皆可刺激IFN-γ顯著的上升，且降低IL-4之分泌，對IL-10、IL17則沒有影響，IFN-γ/IL-4之比值亦明顯的提升，使免疫反應導向Th1；特異性免疫球蛋白的試驗中，三種劑量皆顯著降低特異性IgE，High dose組可顯著降低特異性IgG1。由以上結果顯示，Bifidobacterium longum subsp. infants GB-1640 有調節塵蟎致敏小鼠免疫反應之能力。
URI: http://hdl.handle.net/11455/52009
其他識別: U0005-2308201110030600
Appears in Collections:食品暨應用生物科技學系

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