Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/52119
標題: 萜類化合物在體外及體內對Th1/Th2免疫反應之影響
Effects of terpenoids on Th1/Th2 immune responses in vitro and in vivo
作者: 顧琪玫
Ku, Chi-Mei
關鍵字: 法呢醇;allergic asthma;初代脾臟細胞;萜類化合物;Th1/Th2免疫反應;farnesol;primary splenocytes;terpenoids;Th1/Th2 immune responses
出版社: 食品暨應用生物科技學系所
引用: 苗明三。1997。實驗動物和動物實驗技術。中國中醫藥出版社。P143 林金源。2001。台灣產野生刺莧水萃取物對免疫功能的影響。國立台灣大學農業化學研究所博士論文。 陳佳祺。2010。攝食苦蕎麥對雞卵白蛋白致敏之氣喘模式小鼠免疫調節功能的影響。國立中興大學食品暨應用生物科技學系碩士論文。 Abbas, A. K., Murphy, K. M., & Sher, A. (1996). Functional diversity of helper T lymphocytes. Nature, 383(6603), 787-793. Abdureyim, S., Amat, N., Umar, A., Upur, H., Berke, B., & Moore, N. (2011). Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. Evid Based Complement Alternat Med, 2011. Ahmad, S. F., Khan, B., Bani, S., Suri, K. A., Satti, N. K., & Qazi, G. N. (2006). Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production. Pharmacol Res, 53(3), 233-240. American Institute of Nutrition AIN-76 Semipurified Diet. (1977). Report of the American Institute of Nurtition ad hoc Committee on Standards for Nutritional Studies. J Nutr, 107(7), 1340-1348. Arkestal, K., Sibanda, E., Thors, C., Troye-Blomberg, M., Mduluza, T., Valenta, R., Gronlund, H., & van Hage, M. (2011). Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-alpha 1,3-galactose. J Allergy Clin Immunol, 127(4), 1024-1028. Avci, G., Kucukkurt, I., Kupeli Akkol, E., & Yesilada, E. (2010). Effects of escin mixture from the seeds of Aesculus hippocastanum on obesity in mice fed a high fat diet. Pharm Biol, 48(3), 247-252. Bassole, I. H., Lamien-Meda, A., Bayala, B., Tirogo, S., Franz, C., Novak, J., Nebie, R. C., & Dicko, M. H. (2010). Composition and antimicrobial activities of Lippia multiflora Moldenke, Mentha x piperita L. and Ocimum basilicum L. essential oils and their major monoterpene alcohols alone and in combination. Molecules, 15(11), 7825-7839. Bentinger, M., Grunler, J., Peterson, E., Swiezewska, E., & Dallner, G. (1998). Phosphorylation of farnesol in rat liver microsomes: properties of farnesol kinase and farnesyl phosphate kinase. Arch Biochem Biophys, 353(2), 191-198. Borish, L., Aarons, A., Rumbyrt, J., Cvietusa, P., Negri, J., & Wenzel, S. (1996). Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol, 97(6), 1288-1296. Braga, P. C., Dal Sasso, M., Culici, M., Bianchi, T., Bordoni, L., & Marabini, L. (2006). Anti-inflammatory activity of thymol: inhibitory effect on the release of human neutrophil elastase. Pharmacology, 77(3), 130-136. Caputi, L., & Aprea, E. (2011). Use of terpenoids as natural flavouring compounds in food industry. Recent Pat Food Nutr Agric, 3(1), 9-16. Chavan, M. J., Wakte, P. S., & Shinde, D. B. (2010). Analgesic and anti-inflammatory activity of Caryophyllene oxide from Annona squamosa L. bark. Phytomedicine, 17(2), 149-151. Chen, G., Lu, H., Wang, C., Yamashita, K., Manabe, M., Xu, S., & Kodama, H. (2002). Effect of five triterpenoid compounds isolated from leaves of Diospyros kaki on stimulus-induced superoxide generation and tyrosyl phosphorylation in human polymorphonuclear leukocytes. Clin Chim Acta, 320(1-2), 11-16. Chen, M. L., & Lin, B. F. (2007). Effects of triterpenoid-rich extracts of Ganoderma tsugae on airway hyperreactivity and Th2 responses in vivo. Int Arch Allergy Immunol, 143(1), 21-30. Cheng, H. M., Hsiang, C. Y., Chen, G. W., Wu, S. L., Chen, J. C., Huang, C. Y., Bau, D. T., & Ho, T. Y. (2008). Inhibition of lipopolysaccharide-induced interleukin-1beta and tumor necrosis factor-alpha production by menthone through nuclear factor-kappaB signaling pathway in HaCat cells. Chin J Physiol, 51(3), 160-166. Chu, X., Ci, X., He, J., Wei, M., Yang, X., Cao, Q., Li, H., Guan, S., Deng, Y., Pang, D., & Deng, X. (2011). A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway. Molecules, 16(9), 7634-7648. Ciccio, J. F., & Poveda, L. J. (1999). Volatile constituents of Cunila polyantha (Lamiaceae) from Costa Rica. A rich source of menthone. Rev Biol Trop, 47(3), 377-379. Craig, W. J. (1999). Health-promoting properties of common herbs. Am J Clin. Nutrit, 70 (3 Suppl), 491S-499S. Crottet, P., & Corthesy, B. (1998). Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab'')2: a possible implication for mucosal defense. J Immunol, 161(10), 5445-5453. Curry, E. A., 3rd, Murry, D. J., Yoder, C., Fife, K., Armstrong, V., Nakshatri, H., O''Connell, M., & Sweeney, C. J. (2004). Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Invest New Drugs, 22(3), 299-305. de las Heras, B., & Hortelano, S. (2009). Molecular basis of the anti-inflammatory effects of terpenoids. Inflamm Allergy Drug Targets, 8(1), 28-39. DeBarber, A. E., Bleyle, L. A., Roullet, J. B., & Koop, D. R. (2004). Omega-hydroxylation of farnesol by mammalian cytochromes p450. Biochim Biophys Acta, 1682(1-3), 18-27. Derengowski, L. S., De-Souza-Silva, C., Braz, S. V., Mello-De-Sousa, T. M., Bao, S. N., Kyaw, C. M., & Silva-Pereira, I. (2009). Antimicrobial effect of farnesol, a Candida albicans quorum sensing molecule, on Paracoccidioides brasiliensis growth and morphogenesis. Ann Clin Microbiol Antimicrob, 8, 13. Duncan, R. E., & Archer, M. C. (2008). Farnesol decreases serum triglycerides in rats: identification of mechanisms including up-regulation of PPARalpha and down-regulation of fatty acid synthase in hepatocytes. Lipids, 43(7), 619-627. Fernandes, E. S., Passos, G. F., Medeiros, R., da Cunha, F. M., Ferreira, J., Campos, M. M., Pianowski, L. F., & Calixto, J. B. (2007). Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J Pharmacol, 569(3), 228-236. Gao, J. L., Sen, A. I., Kitaura, M., Yoshie, O., Rothenberg, M. E., Murphy, P. M., & Luster, A. D. (1996). Identification of a mouse eosinophil receptor for the CC chemokine eotaxin. Biochem Biophys Res Commun, 223(3), 679-684. Goto, T., Kim, Y. I., Funakoshi, K., Teraminami, A., Uemura, T., Hirai, S., Lee, J. Y., Makishima, M., Nakata, R., Inoue, H., Senju, H., Matsunaga, M., Horio, F., Takahashi, N., & Kawada, T. (2011). Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPAR{alpha}-dependent and -independent pathways. Am J Physiol Endocrinol Metab. Gouranton, E., Thabuis, C., Riollet, C., Malezet-Desmoulins, C., El Yazidi, C., Amiot, M. J., Borel, P., & Landrier, J. F. (2011). Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue. J Nutr Biochem, 22(7), 642-648. Hamann, L., Stamme, C., Ulmer, A. J., & Schumann, R. R. (2002). Inhibition of LPS-induced activation of alveolar macrophages by high concentrations of LPS-binding protein. Biochem Biophys Res Commun, 295(2), 553-560. Hazlewood, L. C., Wood, L. G., Hansbro, P. M., & Foster, P. S. (2011). Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma. J Nutr Biochem, 22(1), 95-100. Hirota, R., Roger, N. N., Nakamura, H., Song, H. S., Sawamura, M., & Suganuma, N. (2010). Anti-inflammatory effects of limonene from yuzu (Citrus junos Tanaka) essential oil on eosinophils. J Food Sci, 75(3), H87-92. Horn, T. L., Long, L., Cwik, M. J., Morrissey, R. L., Kapetanovic, I. M., & McCormick, D. L. (2005). Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. Chem Biol Interact, 152(2-3), 79-99. Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W. (2001). Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol, 67(7), 2982-2992. Hu, A. P., Du, J. M., Li, J. Y., & Liu, J. W. (2008). Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes. Inflamm Res, 57(4), 163-170. Huang, P., Zhang, S. S., & Zhang, C. (2009). The two sides of cytokine signaling and glaucomatous optic neuropathy. J Ocul Biol Dis Infor, 2(2), 78-83. Inoue, T., Sugimoto, Y., Masuda, H., & Kamei, C. (2001). Effects of peppermint (Mentha piperita L.) extracts on experimental allergic rhinitis in rats. Biol Pharm Bull, 24(1), 92-95. Jan, T. R., Wey, S. P., Kuan, C. C., Liao, M. H., & Wu, H. Y. (2007). Diosgenin, a steroidal sapogenin, enhances antigen-specific IgG2a and interferon-gamma expression in ovalbumin-sensitized BALB/c mice. Planta Med, 73(5), 421-426. Jang, D. S., Min, H. Y., Kim, M. S., Han, A. R., Windono, T., Jeohn, G. H., Kang, S. S., Lee, S. K., & Seo, E. K. (2005). Humulene derivatives from Zingiber zerumbet with the inhibitory effects on lipopolysaccharide-induced nitric oxide production. Chem Pharm Bull (Tokyo), 53(7), 829-831. Jeong, H. G., & Kim, J. Y. (2002). Induction of inducible nitric oxide synthase expression by 18beta-glycyrrhetinic acid in macrophages. FEBS Lett, 513(2-3), 208-212. Juarez, A., Goiriz, R., Sanchez-Perez, J., & Garcia-Diez, A. (2008). Disseminated allergic contact dermatitis after exposure to a topical medication containing geraniol. Dermatitis, 19(3), 163. Juergens, U. R., Engelen, T., Racke, K., Stober, M., Gillissen, A., & Vetter, H. (2004). Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in cultured human lymphocytes and monocytes. Pulm Pharmacol Ther, 17(5), 281-287. Jung, D. H., Park, H. J., Byun, H. E., Park, Y. M., Kim, T. W., Kim, B. O., Um, S. H., & Pyo, S. (2010). Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-kappaB and AP-1 activation. Int Immunopharmacol, 10(9), 1047-1054. Khan, R., & Sultana, S. (2011). Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. Chem Biol Interact, 192(3), 193-200. Kim, D. Y., Park, J. W., Jeoung, D., & Ro, J. Y. (2009). Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model. Eur J Pharmacol, 612(1-3), 98-105. Klopell, F. C., Lemos, M., Sousa, J. P., Comunello, E., Maistro, E. L., Bastos, J. K., & de Andrade, S. F. (2007). Nerolidol, an antiulcer constituent from the essential oil of Baccharis dracunculifolia DC (Asteraceae). Z Naturforsch C, 62(7-8), 537-542. Kohlert, C., Schindler, G., Marz, R. W., Abel, G., Brinkhaus, B., Derendorf, H., Grafe, E. U., & Veit, M. (2002). Systemic availability and pharmacokinetics of thymol in humans. J Clin Pharmacol, 42(7), 731-737. Kracker, S., & Radbruch, A. (2004). Immunoglobulin class switching: in vitro induction and analysis. Methods Mol Biol, 271, 149-159. Kraneveld, A. D., Sagar, S., Garssen, J., & Folkerts, G. (2011). The two faces of mast cells in food allergy and allergic asthma: The possible concept of Yin Yang. Biochim Biophys Acta, 1822(1), 93-99. Lapczynski, A., Bhatia, S. P., Letizia, C. S., & Api, A. M. (2008). Fragrance material review on farnesol. Food Chem Toxicol, 46 Suppl 11, S149-156. Lapczynski, A., Letizia, C. S., & Api, A. M. (2008). Fragrance material review on cis-nerolidol. Food Chem Toxicol, 46 Suppl 11, S245-246. Lee, D. S., Park, W. S., Heo, S. J., Cha, S. H., Kim, D., Jeon, Y. J., Park, S. G., Seo, S. K., Choi, J. S., Park, S. J., Shim, E. B., Choi, I. W., & Jung, W. K. (2011). Polyopes affinis alleviates airway inflammation in a murine model of allergic asthma. J Biosci, 36(5), 869-877. Lee, J. Y., Moon, H., & Kim, C. J. (2010). Effects of hydroxy pentacyclic triterpene acids from Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea pigs. Biol Pharm Bull, 33(2), 230-237. Lee, K. Y., Jung, J. Y., Lee, M. Y., Jung, D., Cho, E. S., & Son, H. Y. (2011). Diospyros blancoi Attenuates Asthmatic Effects in a Mouse Model of Airway Inflammation. Inflammation. Li-Weber, M., Giaisi, M., Treiber, M. K., & Krammer, P. H. (2002). The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T. Eur J Immunol, 32(12), 3587-3597. Li, J., Luo, L., Wang, X., Liao, B., & Li, G. (2009). Inhibition of NF-kappaB expression and allergen-induced airway inflammation in a mouse allergic asthma model by andrographolide. Cell Mol Immunol, 6(5), 381-385. Liao, W., Lin, J. X., & Leonard, W. J. (2011). IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol, 23(5), 598-604. Lin, J. Y., Chen, M. L., & Lin, B. F. (2006). Ganoderma tsugae in vivo modulates Th1/Th2 and macrophage responses in an allergic murine model. Food Chem Toxicol, 44(12), 2025-2032. Lindner, I., Meier, C., Url, A., Unger, H., Grassauer, A., Prieschl-Grassauer, E., & Doerfler, P. (2010). Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation. BMC Immunol, 11, 24. Liu, Y. Q., You, S., Tashiro, S., Onodera, S., & Ikejima, T. (2006). Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells. Int Immunopharmacol, 6(2), 260-268. Mahajan, S. G., & Mehta, A. A. (2011). Suppression of ovalbumin-induced Th2-driven airway inflammation by beta-sitosterol in a guinea pig model of asthma. Eur J Pharmacol, 650(1), 458-464. Martin, S., Padilla, E., Ocete, M. A., Galvez, J., Jimenez, J., & Zarzuelo, A. (1993). Anti-inflammatory activity of the essential oil of Bupleurum fruticescens. Planta Med, 59(6), 533-536. Mathema, V. B., Koh, Y. S., Thakuri, B. C., & Sillanpaa, M. (2011). Parthenolide, a Sesquiterpene Lactone, Expresses Multiple Anti-cancer and Anti-inflammatory Activities. Inflammation. McGarvey, D. J., & Croteau, R. (1995). Terpenoid metabolism. Plant Cell, 7(7), 1015-1026. Medeiros, R., Otuki, M. F., Avellar, M. C., & Calixto, J. B. (2007). Mechanisms underlying the inhibitory actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Eur J Pharmacol, 559(2-3), 227-235. Minogue, A. M., Barrett, J. P., & Lynch, M. A. (2012). LPS-induced release of IL-6 from glia modulates production of IL-1beta in a JAK2-dependent manner. J Neuroinflammation, 9(1), 126. Mitchison, N. A., Schuhbauer, D., & Muller, B. (1999). Natural and induced regulation of Th1/Th2 balance. Springer Semin Immunopathol, 21(3), 199-210. Mo, B. W., Wei, J. H., Huang, J. W., Wang, C. M., Zeng, J. R., Chen, M. X., Zhou, Y., Xu, Q., & Lin, Y. (2010). [Effect of triptolide on airway smooth muscle proliferation and the expression of nuclear factor-kappa B, Bcl-2 in asthmatic rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 26(4), 385-390. Morokata, T., Ishikawa, J., & Yamada, T. (1999). Differential susceptibility of C57BL/6 and DBA/2 mice to ovalbumin-induced pulmonary eosinophilia regulated by Th1/Th2-type cytokines. Immunol Lett, 70(2), 127-134. Muramatsu, M., Ohto, C., Obata, S., Sakuradani, E., & Shimizu, S. (2009). Alkaline pH enhances farnesol production by Saccharomyces cerevisiae. J Biosci Bioeng, 108(1), 52-55. Murphy, K.P., Travers, P., Walport, M., and Janeway, C. (2008). Janeway''s immunobiology, 7th edn (New York, Garkand Science). Nagegowda, D. A. (2010). Plant volatile terpenoid metabolism: biosynthetic genes, transcriptional regulation and subcellular compartmentation. FEBS Lett, 584(14), 2965-2973. Ong, T. P., Heidor, R., de Conti, A., Dagli, M. L., & Moreno, F. S. (2006). Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. Carcinogenesis, 27(6), 1194-1203. Panichi, V., Scatena, A., Migliori, M., Marchetti, V., Paoletti, S., & Beati, S. (2012). Biomarkers of chronic inflammatory state in uremia and cardiovascular disease. Int J Inflam, 2012, 360147. Panossian, A., Hovhannisyan, A., Mamikonyan, G., Abrahamian, H., Hambardzumyan, E., Gabrielian, E., Goukasova, G., Wikman, G., & Wagner, H. (2000). Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine, 7(5), 351-364. Peana, A. T., D''Aquila, P. S., Panin, F., Serra, G., Pippia, P., & Moretti, M. D. (2002). Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils. Phytomedicine, 9(8), 721-726. Qamar, W., & Sultana, S. (2008). Farnesol ameliorates massive inflammation, oxidative stress and lung injury induced by intratracheal instillation of cigarette smoke extract in rats: an initial step in lung chemoprevention. Chem Biol Interact, 176(2-3), 79-87. Qian, N., Chen, X., Han, S., Qiang, F., Jin, G., Zhou, X., Dong, J., Wang, X., Shen, H., & Hu, Z. (2010). Circulating IL-1beta levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women. J Cancer Res Clin Oncol, 136(5), 709-716. Qiu, D., & Kao, P. N. (2003). Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D, 4(1), 1-18. Quintans-Junior, L. J., Souza, T. T., Leite, B. S., Lessa, N. M., Bonjardim, L. R., Santos, M. R., Alves, P. B., Blank, A. F., & Antoniolli, A. R. (2008). Phythochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents. Phytomedicine, 15(8), 619-624. Rivera, D. G., Hernandez, I., Merino, N., Luque, Y., Alvarez, A., Martin, Y., Amador, A., Nuevas, L., & Delgado, R. (2011). Mangifera indica L. extract (Vimang) and mangiferin reduce the airway inflammation and Th2 cytokines in murine model of allergic asthma. J Pharm Pharmacol, 63(10), 1336-1345. Rocha, N. F., Oliveira, G. V., Araujo, F. Y., Rios, E. R., Carvalho, A. M., Vasconcelos, L. F., Macedo, D. S., Soares, P. M., Sousa, D. P., & Sousa, F. C. (2011). (-)-alpha-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration. Eur J Pharm Sci. Rocha, N. F., Rios, E. R., Carvalho, A. M., Cerqueira, G. S., Lopes, A. D., Leal, L. K., Dias, M. L., de Sousa, D. P., & de Sousa, F. C. (2011). Anti-nociceptive and anti-inflammatory activities of (-)-alpha-bisabolol in rodents. Naunyn Schmiedebergs Arch Pharmacol. Rodriguez-Vita, J., & Lawrence, T. (2010). The resolution of inflammation and cancer. Cytokine Growth Factor Rev, 21(1), 61-65. Rogerio, A. P., Andrade, E. L., Leite, D. F., Figueiredo, C. P., & Calixto, J. B. (2009). Preventive and therapeutic anti-inflammatory properties of the sesquiterpene alpha-humulene in experimental airways allergic inflammation. Br J Pharmacol, 158(4), 1074-1087. Rohr, A. C., Wilkins, C. K., Clausen, P. A., Hammer, M., Nielsen, G. D., Wolkoff, P., & Spengler, J. D. (2002). Upper airway and pulmonary effects of oxidation products of (+)-alpha-pinene, d-limonene, and isoprene in BALB/c mice. Inhal Toxicol, 14(7), 663-684. Shchepin, R., Hornby, J. M., Burger, E., Niessen, T., Dussault, P., & Nickerson, K. W. (2003). Quorum sensing in Candida albicans: probing farnesol''s mode of action with 40 natural and synthetic farnesol analogs. Chem Biol, 10(8), 743-750. Shin, H. D., Kim, L. H., Park, B. L., Jung, J. H., Kim, J. Y., Chung, I. Y., Kim, J. S., Lee, J. H., Chung, S. H., Kim, Y. H., Park, H. S., Choi, J. H., Lee, Y. M., Park, S. W., Choi, B. W., Hong, S. J., & Park, C. S. (2003). Association of Eotaxin gene family with asthma and serum total IgE. Hum Mol Genet, 12(11), 1279-1285. Su, Y. W., Chao, S. H., Lee, M. H., Ou, T. Y., & Tsai, Y. C. (2010). Inhibitory effects of citronellol and geraniol on nitric oxide and prostaglandin E production in macrophages. Planta Med, 76(15), 1666-1671. Tantilipikorn, P., & Auewarakul, P. (2011). Airway allergy and viral infection. Asian Pac J Allergy Immunol, 29(2), 113-119. Tao, X., Fan, F., Hoffmann, V., Gao, C. Y., Longo, N. S., Zerfas, P., & Lipsky, P. E. (2008). Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F. Arthritis Rheum, 58(6), 1774-1783. Teixeira, L. K., Fonseca, B. P., Barboza, B. A., & Viola, J. P. (2005). The role of interferon-gamma on immune and allergic responses. Mem Inst Oswaldo Cruz, 100 Suppl 1, 137-144. Thoppil, R. J., & Bishayee, A. (2011). Terpenoids as potential chemopreventive and therapeutic agents in liver cancer. World J Hepatol, 3(9), 228-249. Tilg, H., Trehu, E., Atkins, M. B., Dinarello, C. A., & Mier, J. W. (1994). Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood, 83(1), 113-118. Triantafilou, M., & Triantafilou, K. (2002). Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster. Trends Immunol, 23(6), 301-304. Tripathi, S. S., Mishra, V., Shukla, M., Verma, M., Chaudhury, B. P., Kumar, P., Chhabra, J. K., Pandey, H. P., & Paul, B. (2010). IL-6 receptor-mediated lung Th2 cytokine networking in silica-induced pulmonary fibrosis. Arch Toxicol, 84(12), 947-955. Uemura, T., Goto, T., Kang, M. S., Mizoguchi, N., Hirai, S., Lee, J. Y., Nakano, Y., Shono, J., Hoshino, S., Taketani, K., Tsuge, N., Narukami, T., Makishima, M., Takahashi, N., & Kawada, T. (2011). Diosgenin, the main aglycon of fenugreek, inhibits LXRalpha activity in HepG2 cells and decreases plasma and hepatic triglycerides in obese diabetic mice. J Nutr, 141(1), 17-23. Vasconcelos, J. F., Teixeira, M. M., Barbosa-Filho, J. M., Agra, M. F., Nunes, X. P., Giulietti, A. M., Ribeiro-Dos-Santos, R., & Soares, M. B. (2009). Effects of umbelliferone in a murine model of allergic airway inflammation. Eur J Pharmacol, 609(1-3), 126-131. Vasconcelos, J. F., Teixeira, M. M., Barbosa-Filho, J. M., Lucio, A. S., Almeida, J. R., de Queiroz, L. P., Ribeiro-Dos-Santos, R., & Soares, M. B. (2008). The triterpenoid lupeol attenuates allergic airway inflammation in a murine model. Int Immunopharmacol, 8(9), 1216-1221. Wagner, K. H., & Elmadfa, I. (2003). Biological relevance of terpenoids. Overview focusing on mono-, di- and tetraterpenes. Ann Nutr Metab, 47(3-4), 95-106. Wahlkvist, H., Masjedi, K., Gruvberger, B., Zuber, B., Karlberg, A. T., Bruze, M., & Ahlborg, N. (2008). The lipophilic hapten parthenolide induces interferon-gamma and interleukin-13 production by peripheral blood-derived CD8+ T cells from contact allergic subjects in vitro. Br J Dermatol, 158(1), 70-77. Wang, C. Y., Kao, T. C., Lo, W. H., & Yen, G. C. (2011). Glycyrrhizic acid and 18beta-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-kappaB through PI3K p110delta and p110gamma inhibitions. J Agric Food Chem, 59(14), 7726-7733. Wang, W. C., Kuo, C. Y., Tzang, B. S., Chen, H. M., & Kao, S. H. (2012). IL-6 augmented motility of airway epithelial cell BEAS-2B via Akt/GSK-3beta signaling pathway. J Cell Biochem. Wong, C. K., Ho, C. Y., Ko, F. W., Chan, C. H., Ho, A. S., Hui, D. S., & Lam, C. W. (2001). Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol, 125(2), 177-183. Wu, L. C. (2011). Immunoglobulin E receptor signaling and asthma. J Biol Chem, 286(38), 32891-32897. Yadav, V. R., Prasad, S., Sung, B., Kannappan, R., & Aggarwal, B. B. (2010). Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer. Toxins (Basel), 2(10), 2428-2466. Yang, Y., Luo, C., Feng, R., & Bi, S. (2011). The TNF-alpha, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis. J Cancer Res Clin Oncol, 137(6), 947-952. Yi, J. E., Obminska-Mrukowicz, B., Yuan, L. Y., & Yuan, H. (2010). Immunomodulatory effects of betulinic acid from the bark of white birch on mice. J Vet Sci, 11(4), 305-313. Yomogida, K., Chou, Y., Pang, J., Baravati, B., Maniaci, B. J., Wu, S., Zhu, Y., & Chu, C. Q. (2012). Streptavidin suppresses T cell activation and inhibits IL-2 production and CD25 expression. Cytokine, 58(3), 431-436. Yu, J. S., Kleckley, T. S., & Wiemer, D. F. (2005). Synthesis of farnesol isomers via a modified Wittig procedure. Org Lett, 7(22), 4803-4806. Zhang, Y., & Ma, X. (2010). Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha. J Immunol, 184(7), 3866-3877. Zhou, J. Y., Tang, F. D., Mao, G. G., & Bian, R. L. (2004). Effect of alpha-pinene on nuclear translocation of NF-kappa B in THP-1 cells. Acta Pharmacol Sin, 25(4), 480-484. Zhou, Z. L., Yang, Y. X., Ding, J., Li, Y. C., & Miao, Z. H. (2012). Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms. Nat Prod Rep, 29(4), 457-475. Zore, G. B., Thakre, A. D., Jadhav, S., & Karuppayil, S. M. (2011). Terpenoids inhibit Candida albicans growth by affecting membrane integrity and arrest of cell cycle. Phytomedicine, 18(13), 1181-1190. http://www.biocompare.com/Application-Notes/43518-Th1-And-Th2-Balance-Regulation-And-Involvement-In-Disease/ (搜尋日期July 3, 2012)
摘要: 
萜類化合物又稱異戊二烯化合物,廣泛存在於天然植物中,為植物重要的二次代謝產物,依據組成的單位數可分為單萜、倍半萜、雙萜、三萜及四萜化合物,研究指出萜類化合物具有抗發炎、抗氧化、抗菌及抗癌之功效,但對過敏性氣喘之研究仍缺乏。過敏性氣喘為一種呼吸道慢性發炎疾病,患者體內免疫反應傾向輔助型T細胞第2型(helper T cells 2, Th2),若能調節人體內Th1/Th2細胞平衡,應能改善氣喘發生的症狀,為篩選具有抗過敏性氣喘潛力的物質,本實驗選取27種可能具有免疫調節潛力的萜類化合物,首先探討其在體外試驗對初代脾臟細胞Th2/Th1免疫反應之影響,測定Th1及Th2細胞激素分泌的變化,結果顯示法呢醇降低interleukin (IL)-10/IL-2細胞激素比值,具有使免疫反應傾向Th1的潛力。接著探討法呢醇對以ovalbumin (OVA)致敏及吸入的BALB/c小鼠免疫調節之影響,結果顯示餵食法呢醇5週可降低腹腔細胞促發炎(tumer necrosis factor-α, TNF-α)/抗發炎(IL-10)細胞激素比值、降低血清中OVA特異性抗體和非特異性抗體含量,增加血清中high-density lipoprotein cholesterol (HDL-c)數值,顯示法呢醇可使氣喘小鼠體內免疫平衡傾向Th1免疫反應,減緩過敏發炎反應。綜合體外及體內實驗結果證實倍半萜類法呢醇具有調節Th1/Th2免疫反應之作用,可降低過敏性疾病的發生。

Terpenoids, also called isoprenoids, are a group of compounds that exist in
nearly every natural plant and most of them are important secondary metabolites in plant. Based on the number of building blocks, terpenoids are classified into monoterpenoids, sesquiterpenoids, diterpenoids, triterpenoids and tetraterpenoids. Several studies have evidenced that terpenoids have beneficial impact in body for anti-inflammatation, anti-oxidantion, anti-biotic effect and anti-cancer; however, effects of terpenoids on allergic asthma remain unclear. Allergic asthma is a chronic airway inflammatory disease, resulting from helper T cells type 2 (Th2)-skewed immune responses. Thus, asthma may be improved through modulating Th1/Th2 immune balance. To screen potent compounds for allergic asthma treatment, this study selected 27 terpenoids with immunomodulatory potential and investigated their effects on Th1/Th2 immune responses using primary splenocytes in vitro. Th1 and Th2 cytokines were determined using ELISA. The results showed that farnesol reduced interleukin (IL)-10/IL-2 cytokine ratios in a dose-dependent manner, suggesting that farnesol might modulate Th2/Th1 balance toward Th1 immune response. Therefore, farnesol was further administered to ovalbumin (OVA)-sensitized and -challenged BALB/c mice for 5 weeks. The results showed that farnesol supplementation decreased pro-inflammatory (tumer necrosis factor-α, TNF-α)/anti-inflammatory (IL-10) cytokine secretion ratios by peritoneal cells, and serum OVA-specific and non-specific antibody titers, but increased high-density lipoprotein cholesterol (HDL-c) level in sera. These results suggested that farnesol might modulate Th2 immune responses toward Th1 balance in allergic asthmatic mice and alleviate allergic inflammation responses. In conclusion, the sesquiterpenoid farnesol may modulate Th1/Th2 immune responses in vitro and in vivo and improve allergic diseases.
URI: http://hdl.handle.net/11455/52119
其他識別: U0005-0908201218523300
Appears in Collections:食品暨應用生物科技學系

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