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標題: Bifidobacterium longum B7與金針菇水溶性多醣對C57BL/6JNarl小鼠調節血糖、血脂以及改善腸胃功能之影響
Effects of Bifidobacterium longum B7 and water-soluble polysaccharide from Flammulina velutipes on blood glucose, plasma lipids and gastrointestinal function in C57BL/6JNarl mice
作者: 吳泰駿
Wu, Tai-Jun
關鍵字: 乳酸菌;Lactic acid bacteria;金針菇;膽固醇;三酸甘油脂;葡萄糖耐受性試驗;Flammulina velutipes;cholesterol;triglycerides;glucose intolerance test
出版社: 食品暨應用生物科技學系所
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乳酸菌被認為具有多種的保健功效,其中包括抗發炎、降血脂、調節免疫、減緩過敏、減緩乳糖不耐症。另外有研究提到菇類多醣具有降血糖、降血脂、改善腸道菌相的功效。本研究為探討Bifidobacterium longum B7結合不同劑量的金針菇水溶性多醣。對於C57BL/6JNarl小鼠血脂、血糖、腸胃道功能的影響。實驗組餵食高脂飲食持續8週後,結果顯示高劑量多醣和B. longum B7能明顯減少體重增加、減少腹部脂肪累積、降低血液中總膽固醇、LDL-C (p <0.05)。B. longum B7結合多醣能提高糞便膽固醇排出量(p <0.05),並且B. longum B7和多醣能降低肝臟膽固醇、肝臟三酸甘油脂以及禁食血糖(p <0.05),但無法改善葡萄糖耐受性不佳的情形。糞便菌相顯示,B. longum B7和多醣能促進腸道乳酸菌和Bifidobacterium spp.生長(p <0.05)。因此本實驗證實乳酸以及金針菇水溶性多醣能調節血脂、改善腸胃功能。

Lactic acid bacteria (LAB) have been considered as probiotics to improve and maintain health, which can reduce inflammatory response, reducing serum cholesterol, regulating immunity, moderating allergy symptoms and reducing lactose intolerance. Other studies indicated mushroom polysaccharides contain many health benifits, including the decrease in serum cholesterol and blood glucose level and modification of intestinal microbiota.The study aims to evaluate the effect of Bifidobacterium longum B7 and water-soluble polysaccharide from Flammulina velutipes on plasma lipids, glucose and gastrointestinal function in C57BL/6JNarl mice. The experimental groups were fed the high fat diet (HFD) for 8 weeks, Results indicate that high dose of polysaccharide and B. longum B7 reduced body weight gain, accumulation of abdominal fat, serum total cholesterol and LDL-C(p <0.05). B. longum B7 combined with polysaccharides increased fecal cholesterol excretion(p <0.05). B. longum B7 and polysaccharides reduced hepatic cholesterol, triglycerides and fasting blood glucose(p <0.05). However, there were no significant differences in oral glucose intolerance test. Besides, administration of B. longum B7 and polysaccharides also promoted the growth of LAB and Bifidobacterium spp(p <0.05). In conclusion, these data indicate that B. longum B7 and water-soluble polysaccharide (Flammulina velutipes) have hypolipidemic effect and improvement of gastrointestinal function.
其他識別: U0005-2308201315440200
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