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The Research of Urban Management, Organizational Effectiveness, Civic Communication and Urban Marketing for the Local Government
|作者:||吳志文||關鍵字:||sustainable development;應用研究;環保工程;good governance;capacity-building;citizen communication and urban marketing||摘要:||
The main purpose of the research is to examine how to improve urban marketing strategy andapproach to achieve the goal of sustainable development. Urban competitive advantage is arelative comparison concept. If a city owns good governance and capacity-building, this canattract more business investment for maintaining unique characteristics and competitiveadvantages by implementing urban marketing. A set of urban marketing activities could bean effective policy instrument to achieve the goal of sustainability development. Traditionally,when a economic development was planned by the national government, the government willconsider major region, industry and national citizen as a focus subject. However, thegovernment seldom thinks about resource limitation for resulting in inefficient performance.Generally, the government use resource allocation policy to balance the difference of urbanand rural area. However, if the government can not implement the urban marketing strategyeffectively, the difference of urban and rural area will increase. The literature of goodgovernance, capacity-building, citizen communication and urban marketing will be reviewed.This proposal suggests the authority review and renews indicators systems regularly.Meanwhile, the main issue is how to implement good governance, capacity-building, citizencommunication and urban marketing toward sustainability.
Cdk5 (cyclin-dependent kinase 5) belongs to CDK family. However, the activator of Cdk5 is not cyclin, but p35. The investigation of Cdk5 was primarily focused on the roles in central nervous system including neurodegenerative diseases. Principle investigator's published results indicate that Cdk5 can regulate proliferation of both thyroid cancer cells and prostate cancer cells through specific mechanisms. As regards to breast cancer, principle investigator's preliminary results showed the positive correlation between Cdk5/p35 levels and breast cancer cell proliferation (see the preliminary data 3). Clinical data also confirmed that protein levels of Cdk5/p35 in tumor tissues were higher than those in normal ones (patients' specimen was provided from Chang Bing Show Chwan Memorial Hospital due to collaboration) (see the preliminary data 1 and 2). Therefore, the goal of this grant is to investigate the roles and mechanisms of Cdk5/p35 which regulate the biological functions of breast cancer cells. The strategies are: 1. Investigate the effects of different Cdk5/p35 levels or activity (includes mutants) on biological functions of breast cancer cells (includes proliferation, cell cycle, apoptosis, adhesion, migration, and invasion). 2. Evaluate whether tyrosine kinases, such as EGFR, Her2, and c-Abl, as upstream factors, can directly or indirectly regulate Cdk5/p35 protein expression or activity. 3. Evaluate whether ERα, p53, p21WAP/Cip1, STAT3, TC10α, c-cbl can be directly or indirectly regulated by Cdk5/p35 as downstream factors (observe transcriptional activity, protein stability, subcellular localization, cytoskeletal change). 4. Take advantage of nude mice xenograft model to testify the hypothetical findings from breast cancer cell lines. 5. Using the commercial tissue array chips of breast cancer (IRB unnecessary) to testify the hypothetical correlation among Cdk5/p35 and those proteins described above. Base on these experimental designs, principle investigator expects to understand the roles of Cdk5/p35 in breast cancer from the view points of basic research and hope these outcomes in the future can contribute to the diagnosis and treatment of breast cancer.
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