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A Research into the Effects of Bitter Buckwheat on Allergic Asthma Using an Ovalbumin-Sensitized and -Challenged Mouse Model
|作者:||林金源||關鍵字:||應用研究;Bitter Buckwheat;食品科技, 基礎醫學類;苦蕎麥;過敏性氣喘;抗發炎作用;卵白蛋白致敏及刺激的小鼠模式;Allergic Asthma;Anti-inflammatory Effects;Ovalbumin-sensitized and -challenged Mouse Model||摘要:||
This study is “A research into the effects of bitter buckwheat on allergic asthma using an ovalbumin-sensitized and -challenged mouse model”. The objective of the project is to evaluate the effects of bitter buckwheat cultivated in Taiwan on allergic asthma through 5-weeks consecutive feeding. The immunomodulatory and anti-inflammatory functions against systemic and local airway inflammation will be investigated using an established ovalbumin (OVA)-sensitized and -challenged mouse model. The investigation upon the effects of bitter buckwheat products on immune responses in both the spleen and the airways will be finished in this year. To judge the effects of bitter buckwheat on allergic asthma, levels of secreted cytokines and mediators, including Th1 and Th2 cytokines, or chemokines…etc., in the splenocyte cultures and bronchoalveolar lavage fluid (BALF) from OVA-challenged BALB/c mice will be determined. Titers of non-specific and OVA-specific antibodies in sera will also be determined using an ELISA. The ultimate goal of this project is to provide the scientific evidences of the possibility of alleviating allergic asthmatic inflammation by different products of bitter buckwheat. Based on the results from this study, bitter buckwheat may develop to be a functional food for preventing or alleviating allergic asthma. As this project is finished, the goals will be achieved as follows:1. To understand the total effects of bitter buckwheat as a staple food on allergic asthma, including immune systems and blood lipids.2. To characterize immunomodulatory effects of bitter buckwheat on Th1/Th2 immune balance in vivo. 3. To understand the effects of bitter buckwheat on allergic asthmatic inflammation. especially in the airways.4. To judge the anti-allergic effects of bitter buckwheat according to the secretion profiles of eotaxin levels in the airways of OVA-challenged mice.5. To provide a scientific evidence of bitter buckwheat about its immunomodulatory function in vivo.6. To train graduate students which take part in this project to be experts in evaluating health foods in Taiwan.
|Appears in Collections:||食品暨應用生物科技學系|
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