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|標題:||Molecular epidemiology of Shigella in a Taiwan township during 1996 to 2000||作者:||Chen, J.H.
|關鍵字:||she pathogenicity island;chromosomal dna;flexneri 2a;salmonella;deletion;virulence;children||Project:||Journal of Clinical Microbiology||期刊/報告no：:||Journal of Clinical Microbiology, Volume 41, Issue 7, Page(s) 3078-3088.||摘要:||
A previously identified Shigella flexneri serotype 2a strain was responsible for an outbreak of shigellosis in a Taiwan township in August 1996. In order to find the relationship between this outbreak strain and subsequent Shigella infections in the area, 59, 47, 35, and 20 Shigella isolates recovered in 1997, 1998, 1999, and 2000, respectively, were collected and typed by serological and pulsed-field gel electrophoresis (PFGE) techniques. Of these 161 isolates, 139 isolates were S. flexneri serotype 2a, and one-third of them (47 isolates) exhibited the outbreak pattern. The remaining 92 S. flexneri serotype 2a isolates displayed 49 different NotI-PFGE patterns. Forty-five patterns were closely related to the outbreak pattern, with deletions of three specific NotI fragments occurring with high frequency. While the outbreak strain remained the main cause of shigellosis after the outbreak, the continuous emergence of closely related though poorly transmissible strains from the outbreak strain contributed to the observed annual decrease of shigellosis in the area.
|Appears in Collections:||分子生物學研究所|
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