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標題: Molecular epidemiology of Mycobacterium abscessus infections in a subtropical chronic ventilatory setting
作者: Huang, W.C.
Chiou, C.S.
Chen, J.H.
Shen, G.H.
關鍵字: field gel-electrophoresis;length polymorphism analysis;nontuberculous;mycobacteria;rapid identification;hsp65 gene;heterogeneity;tuberculosis;fortuitum;patterns;diseases
Project: Journal of Medical Microbiology
期刊/報告no:: Journal of Medical Microbiology, Volume 59, Issue 10, Page(s) 1203-1211.
The aim of this study was to investigate the high level of pulmonary Mycobacterium abscessus infections and implement a surveillance programme among 43 ventilator-dependent patients, 15 with pulmonary M abscessus infections, in a hospital long-term respiratory care ward (RCW) in central Taiwan M. abscessus isolates were obtained from 35 patients in the RCW of hospital A, 6 patients in the RCWs of another three hospitals (B, C and D), and from 4 water sources in two of the hospitals (A and B). Strains were characterized by methods including hsp65 PCR-RFLP and PFGE. The patients were followed-up by chest X-ray for 1 year All clinical isolates were type I and II, and belonged to ten distinct clusters of PFGE patterns. Five clinical strains in two hospitals belonged to a single cluster, whilst four clinical strains in the other two hospitals belonged to a single unique cluster The strains from hospital A fell into nine clusters and were distinct from the strains isolated from the water supply. Patients infected with type I strains showed a significantly more rapid progression of disease. The number of different strains involved suggested either that there had been a polyclonal outbreak or that a high level of endemic infections was present in the RCW of hospital A This and the lack of homology between the clinical and environmental isolates from hospital A raised the possibility that pulmonary M abscessus infections may have been spread by the movement of patients between RCWs, a routine practice in Taiwan's integrated delivery system
ISSN: 0022-2615
DOI: 10.1099/jmm.0.020586-0
Appears in Collections:分子生物學研究所

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