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|標題:||Antigenic diversity of Neisseria meningitidis isolated in Taiwan between 1995 and 2002||作者:||Yang, C.Y.
|關鍵字:||membrane vesicle vaccine;meningococcal disease;lipooligosaccharide;immunotype;antibody-responses;hexavalent pora;capsule;immunization;protein;outbreak;strains||Project:||Scandinavian Journal of Infectious Diseases||期刊/報告no：:||Scandinavian Journal of Infectious Diseases, Volume 38, Issue 4, Page(s) 273-280.||摘要:||
The geographic distribution of N. meningitidis is diverse. Information on the antigenic variation of N meningitidis is important for the development of an outer membrane protein-based vaccine. As a first step towards vaccine development, serological typing was performed to determine the antigenic properties of 127 invasive N meningitidis isolates collected in Taiwan between 1995 and 2002. With 31.5% non-serotypeable and 32.3% non-serosubtypeable, the 127 isolates fell into 51 phenotypes, with W135:NT:P1.5,2:L3,7,9, Y:14P1.5,2, and B:1:NST:L3,7,9 being the 3 most prevalent. Among the 37 serogroup B isolates, 15 serosubtypes were found, with P1.5,2 and P1.12,13 being the most prevalent. The high diversity of Por A among serogroup B isolates circulating in Taiwan poses a great challenge for the development of a PorA-based vaccine. Because 85% of the serogroup B isolates had the L3,7,9 immunotype, inclusion of L3,7,9 lipooligosaccharides in a PorA-based vaccine may be a promising approach. In addition, based on the phenotypic characterization, we suggest that both serogroup B and W135 isolates were endemic and that serogroup A, C, and Y isolates were imported, which may reflect increased international travel.
|Appears in Collections:||分子生物學研究所|
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