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標題: Cucurbitane Triterpenoids from Momordica charantia and Their Cytoprotective Activity in tert-Butyl Hydroperoxide-Induced Hepatotoxicity of HepG2 Cells
作者: Chen, C.R.
Liao, Y.W.
Wang, L.
Kuo, Y.H.
Liu, H.J.
Shih, W.L.
Cheng, H.L.
Chang, C.I.
關鍵字: Chinese herb;Momordica charantia;Cucurbitaceae;pentanorcucurbitane;trinorcucurbitane;cytoprotective;glycosides;constituents;fruit;stems
Project: Chemical & Pharmaceutical Bulletin
期刊/報告no:: Chemical & Pharmaceutical Bulletin, Volume 58, Issue 12, Page(s) 1639-1642.
Two novel pentanorcucurbitane triterpenes, 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one (1) and 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-mc acid (2) together with a new trinorcucurbitane triterpene, 25,26,27-trinorcucurbit-5-ene-3,7,23-trione (3) were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods. Compounds 2 and 3 showed potent cytoprotective activity in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity of HepG2 cells.
ISSN: 0009-2363
DOI: 10.1248/cpb.58.1639
Appears in Collections:分子生物學研究所

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