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|標題:||Cucurbitane Triterpenoids from Momordica charantia and Their Cytoprotective Activity in tert-Butyl Hydroperoxide-Induced Hepatotoxicity of HepG2 Cells||作者:||Chen, C.R.
|關鍵字:||Chinese herb;Momordica charantia;Cucurbitaceae;pentanorcucurbitane;trinorcucurbitane;cytoprotective;glycosides;constituents;fruit;stems||Project:||Chemical & Pharmaceutical Bulletin||期刊/報告no：:||Chemical & Pharmaceutical Bulletin, Volume 58, Issue 12, Page(s) 1639-1642.||摘要:||
Two novel pentanorcucurbitane triterpenes, 22-hydroxy-23,24,25,26,27-pentanorcucurbit-5-en-3-one (1) and 3,7-dioxo-23,24,25,26,27-pentanorcucurbit-5-en-22-mc acid (2) together with a new trinorcucurbitane triterpene, 25,26,27-trinorcucurbit-5-ene-3,7,23-trione (3) were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods. Compounds 2 and 3 showed potent cytoprotective activity in tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity of HepG2 cells.
|Appears in Collections:||分子生物學研究所|
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