Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/60399
DC FieldValueLanguage
dc.contributor.authorLin, F.L.en_US
dc.contributor.author劉宏仁zh_TW
dc.contributor.authorHsu, J.L.en_US
dc.contributor.authorChou, C.H.en_US
dc.contributor.authorWu, W.J.en_US
dc.contributor.authorChang, C.I.en_US
dc.contributor.authorLiu, H.J.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-09T05:56:25Z-
dc.date.available2014-06-09T05:56:25Z-
dc.identifier.issn0014-2999zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/60399-
dc.description.abstractThe effect of the natural compound damnacanthal from Morinda citrifolia on SKHep 1 cell growth regulation was investigated Treatment of SKHep 1 cells with damnacanthal for 24 h indicated a dose dependent antiproliferative activity Damnacanthal seems to be selective for tumor cell lines since there is only minimal toxicity against normal hepatocyte cells (FL83B) This is first demonstration that damnacanthal mediated apoptosis involves the sustained activation of the p38 MAPK pathway leading to the transcription of the death receptor family genes encoding DR5/TRAIL and TNF R1/TNF-alpha genes as well as the p53-regulated Bax gene The damnacanthal mediated expression of DR5/TRAIL and TNF R1/TNF-alpha results in caspase 8 activation leading to Bid cleavage In turn activated Bid acting with p53-regulated Bax leads to cytochrome c released from mitochondria Into the cytoplasm Combined activation of the death receptors and mitochondrial pathways results in activation of the downstream effecter caspase 3 leading to cleavage of PARP TRAIL- and TNF a-mediated damnacanthal-induced apoptosis could be suppressed by treatment with caspase inhibitors as well as soluble death receptors Fc DR5 and Fc TNF-R1 chimera Taken together this study provided first evidence demonstrating that TRAIL- INF-alpha and p53-mediated damnacanthal-induced apoptosis require the activation of p38 MAPK and mitochondrion mediated caspase-dependent pathways (C) 2010 Elsevier BV All rights reserveden_US
dc.language.isoen_USzh_TW
dc.relationEuropean Journal of Pharmacologyen_US
dc.relation.ispartofseriesEuropean Journal of Pharmacology, Volume 650, Issue 1, Page(s) 120-129.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.ejphar.2010.10.005en_US
dc.subjectDamnacanthalen_US
dc.subjectMorinda citrifoliaen_US
dc.subjectp38 MAPKen_US
dc.subjectTRAILen_US
dc.subjectTNF alphaen_US
dc.subjectp53en_US
dc.subjectprotein-kinase inhibitorsen_US
dc.subjectligand-induced apoptosisen_US
dc.subjectcytochrome-cen_US
dc.subjectreleaseen_US
dc.subjectsignal-transductionen_US
dc.subjectmorinda-citrifoliaen_US
dc.subjectcaspase activationen_US
dc.subjectmitochondriaen_US
dc.subjectdeathen_US
dc.subjectjnken_US
dc.subjectinductionen_US
dc.titleActivation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF-alpha and p53 pathwaysen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.ejphar.2010.10.005zh_TW
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
Appears in Collections:分子生物學研究所
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