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|標題:||Genetic variation of the lambda A and lambda C protein encoding genes of avian reoviruses||作者:||Shen, P.C.
|關鍵字:||avian reovirus;lambda A and lambda C proteins;L1 and L3 gene segment;phylogenetic analysis;amino-terminal region;messenger-rna;genome segments;mu-ns;phylogenetic analysis;nucleic-acids;binding-site;sigma-ns;identification;guanylyltransferase||Project:||Research in Veterinary Science||期刊/報告no：:||Research in Veterinary Science, Volume 83, Issue 3, Page(s) 394-402.||摘要:||
Sequence and phylogenetic analysis of lambda A and lambda C protein encoding genes of 12 avian reoviruses is described. The sequence of lambda A possesses a variable region (residues 19-51) located within a conserved hydrophilic region (residues 1-110) and a C,H, zinc-binding motif (residues 182-202). lambda C shows the two conserved K residues at positions 169 and 188 indicative of guanylyltransferase activity, an ATP/ GTP-binding site motif A (residues 379-386), and a conserved S-adenosyl-L-methionine-binding motif (residues 822-830). Pairwise sequence comparisons show that the mean sequence identities of lambda A encoding genes and lambda A proteins are 92% and 98%, respectively, and those of lambda C encoding genes and lambda C proteins are 91% and 95%, respectively. Phylogenetic analysis of lambda A and lambda C encoding genes reveals that both encoding genes have diverged into three distinct lineages, respectively, and that there is no correlation between lineages and viral serotypes or pathotypes. Also, reassortment of gene segments L1 and L3 has been observed between viruses. (C) 2007 Elsevier Ltd. All rights reserved.
|Appears in Collections:||分子生物學研究所|
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