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標題: Effect of Arctium lappa L. in the dextran sulfate sodium colitis mouse model
作者: Huang, T.C.
Tsai, S.S.
Liu, L.F.
Liu, Y.L.
Liu, H.J.
Chuang, K.P.
關鍵字: Arctium lappa L.;Colitis;Cytokine;Inflammatory bowel disease;Ulcerative colitis;fatty-acids;inflammation;diseases;extract
Project: World Journal of Gastroenterology
期刊/報告no:: World Journal of Gastroenterology, Volume 16, Issue 33, Page(s) 4193-4199.
AIM: To analyze the possible protective role of Arctium lappa L. (AL) in a murine model of ulcerative colitis (UC). METHODS: BALB/c mice were administered 100 mg/kg AL powder orally each day. After 7 d, colitis was induced by administration of dextran sulfate sodium (DSS) (5% W/V) in drinking water for a further 8 consecutive days. Diarrhea and bloody stools as well as colonic histology were observed. The level of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in colonic sections were detected by immunohistochemistry. RESULTS: There were significant differences in mean body weight values and disease activity indices between controls and AL-treated animals. Moreover, the histological findings showed that AL treatment can prevent mucosal edema, submucosal erosions, ulceration, inflammatory cell infiltration and colon damage. In addition, immunohistochemistry analysis showed that the levels of the inflammatory cytokines, IL-6 and TNF-alpha were also decreased in AL-treated groups. CONCLUSION: We suggest that AL can prevent intestinal damage and decrease inflammatory cytokines in mice with DSS-induced colitis. Thus, AL could prove to be a useful food for UC. (C) 2010 Baishideng. All rights reserved.
ISSN: 1007-9327
DOI: 10.3748/wjg.v16.i33.4193
Appears in Collections:分子生物學研究所

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