Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/60431
DC FieldValueLanguage
dc.contributor.authorLi, L.Y.en_US
dc.contributor.author賴建成zh_TW
dc.contributor.authorChen, H.Y.en_US
dc.contributor.authorHsieh, Y.H.en_US
dc.contributor.authorWang, Y.N.en_US
dc.contributor.authorChu, H.J.en_US
dc.contributor.authorChen, Y.H.en_US
dc.contributor.authorChien, P.J.en_US
dc.contributor.authorMa, H.T.en_US
dc.contributor.authorTsai, H.C.en_US
dc.contributor.authorLai, C.C.en_US
dc.contributor.authorSher, Y.P.en_US
dc.contributor.authorLien, H.C.en_US
dc.contributor.authorTsai, C.H.en_US
dc.contributor.authorHung, M.C.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-09T05:56:29Z-
dc.date.available2014-06-09T05:56:29Z-
dc.identifier.issn0008-5472zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/60431-
dc.description.abstractAberrant regulation of rRNA synthesis and translation control can facilitate tumorigenesis. The ErbB2 growth factor receptor is overexpressed in many human tumors and has been detected in the nucleus, but the role of nuclear ErbB2 is obscure. In this study, we defined a novel function of nuclear ErbB2 in enhancing rRNA gene transcription by RNA polymerase-I (RNA Pol I). Nuclear ErbB2 physically associates with beta-actin and RNA Pol I, coinciding with active RNA Pol I transcription sites in nucleoli. RNA interference-mediated knockdown of ErbB2 reduced pre-rRNA and protein synthesis. In contrast, wild-type ErbB2 augmented pre-rRNA level, protein production, and cell size/cell growth, but not by an ErbB2 mutant that is defective in nuclear translocation. Chromatin immunoprecipitation assays revealed that ErbB2 enhances binding of RNA Pol I to rDNA. In addition, ErbB2 associated with rDNA, RNA Pol I, and b-actin, suggesting how it could stimulate rRNA production, protein synthesis, and increased cell size and cell growth. Finally, ErbB2-potentiated RNA Pol I transcription could be stimulated by ligand and was not substantially repressed by inhibition of PI3-K and MEK/ERK (extracellular signal regulated kinase), the main ErbB2 effector signaling pathways. Together, our findings indicate that nuclear ErbB2 functions as a regulator of rRNA synthesis and cellular translation, which may contribute to tumor development and progression. Cancer Res; 71(12); 4269-79. (C)2011 AACR.en_US
dc.language.isoen_USzh_TW
dc.relationCancer Researchen_US
dc.relation.ispartofseriesCancer Research, Volume 71, Issue 12, Page(s) 4269-4279.en_US
dc.relation.urihttp://dx.doi.org/10.1158/0008-5472.can-10-3504en_US
dc.titleNuclear ErbB2 Enhances Translation and Cell Growth by Activating Transcription of Ribosomal RNA Genesen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1158/0008-5472.can-10-3504zh_TW
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:分子生物學研究所
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