Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/60440
DC FieldValueLanguage
dc.contributor.authorLin, Y.J.en_US
dc.contributor.author賴建成zh_TW
dc.contributor.authorWan, L.en_US
dc.contributor.authorHuang, C.M.en_US
dc.contributor.authorSheu, J.J.C.en_US
dc.contributor.authorChen, S.Y.en_US
dc.contributor.authorLin, T.H.en_US
dc.contributor.authorChen, D.Y.en_US
dc.contributor.authorHsueh, K.C.en_US
dc.contributor.authorLai, C.C.en_US
dc.contributor.authorTsai, F.J.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-09T05:56:30Z-
dc.date.available2014-06-09T05:56:30Z-
dc.identifier.issn0392-856Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/60440-
dc.description.abstractObjective The genetic control of Interleukin-10 (IL-10) and Tumour necrosis factor-alpha (TNF-alpha) production and the possible interaction between the two cytokines in influencing SLE susceptibility as well as clinical features has not been completely evaluated in the Taiwanese population. Methods We investigated the association of IL-10 and TNF-alpha promoter polymorphisms (-1082, -819 and -592 for IL-10 gene; -308 for TNF-alpha gene) with SLE in a total of 172 Taiwanese patients and 215 controls. Results Our results indicate that IL-10 A/T/A-A/T/A genotype was associated with Taiwanese SLE, whereas no significance was observed between TNF-alpha genotype and SLE. Furthermore, the TNF-alpha G allele frequency of the polymorphism at -308 was significantly decreased in patients with oral ulcers. The combined frequencies of IL-10 A/T/A haplotype and TNF-alpha G-G genotype were significantly increased in SLE patients. In addition, the combined frequencies of IL-10 A/T/A haplotype and TNF-alpha G-G genotype were significantly decreased in patients with oral ulcers. Conclusion These results suggest a significant correlation of the combined IL-10 and TNF-alpha genetic polymorphisms contribute to SLE susceptibility and clinical features in the Taiwanese population.en_US
dc.language.isoen_USzh_TW
dc.relationClinical and Experimental Rheumatologyen_US
dc.relation.ispartofseriesClinical and Experimental Rheumatology, Volume 28, Issue 3, Page(s) 318-324.en_US
dc.subjectSystemic lupus erythematosusen_US
dc.subjectinterleukin-10en_US
dc.subjecttumour necrosisen_US
dc.subjectfactor-alphaen_US
dc.subjectsingle nucleotide polymorphismen_US
dc.subjecttumor-necrosis-factoren_US
dc.subjectinterleukin-10 gene promoteren_US
dc.subjectdisease-activityen_US
dc.subjecthaplotype reconstructionen_US
dc.subjectrheumatic-diseasesen_US
dc.subjectchinese patientsen_US
dc.subjectthaien_US
dc.subjectpopulationen_US
dc.subjectsleen_US
dc.subjectassociationsen_US
dc.subjectallelesen_US
dc.titleIL-10 and TNF-alpha promoter polymorphisms in susceptibility to systemic lupus erythematosus in Taiwanen_US
dc.typeJournal Articlezh_TW
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:分子生物學研究所
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