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標題: IL-10 and TNF-alpha promoter polymorphisms in susceptibility to systemic lupus erythematosus in Taiwan
作者: Lin, Y.J.
Wan, L.
Huang, C.M.
Sheu, J.J.C.
Chen, S.Y.
Lin, T.H.
Chen, D.Y.
Hsueh, K.C.
Lai, C.C.
Tsai, F.J.
關鍵字: Systemic lupus erythematosus;interleukin-10;tumour necrosis;factor-alpha;single nucleotide polymorphism;tumor-necrosis-factor;interleukin-10 gene promoter;disease-activity;haplotype reconstruction;rheumatic-diseases;chinese patients;thai;population;sle;associations;alleles
Project: Clinical and Experimental Rheumatology
期刊/報告no:: Clinical and Experimental Rheumatology, Volume 28, Issue 3, Page(s) 318-324.
Objective The genetic control of Interleukin-10 (IL-10) and Tumour necrosis factor-alpha (TNF-alpha) production and the possible interaction between the two cytokines in influencing SLE susceptibility as well as clinical features has not been completely evaluated in the Taiwanese population. Methods We investigated the association of IL-10 and TNF-alpha promoter polymorphisms (-1082, -819 and -592 for IL-10 gene; -308 for TNF-alpha gene) with SLE in a total of 172 Taiwanese patients and 215 controls. Results Our results indicate that IL-10 A/T/A-A/T/A genotype was associated with Taiwanese SLE, whereas no significance was observed between TNF-alpha genotype and SLE. Furthermore, the TNF-alpha G allele frequency of the polymorphism at -308 was significantly decreased in patients with oral ulcers. The combined frequencies of IL-10 A/T/A haplotype and TNF-alpha G-G genotype were significantly increased in SLE patients. In addition, the combined frequencies of IL-10 A/T/A haplotype and TNF-alpha G-G genotype were significantly decreased in patients with oral ulcers. Conclusion These results suggest a significant correlation of the combined IL-10 and TNF-alpha genetic polymorphisms contribute to SLE susceptibility and clinical features in the Taiwanese population.
ISSN: 0392-856X
Appears in Collections:分子生物學研究所

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