Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/60459
DC FieldValueLanguage
dc.contributor.authorHsu, W.Y.en_US
dc.contributor.author賴建成zh_TW
dc.contributor.authorLo, W.Y.en_US
dc.contributor.authorLai, C.C.en_US
dc.contributor.authorTsai, F.J.en_US
dc.contributor.authorTsai, C.H.en_US
dc.contributor.authorTsai, Y.en_US
dc.contributor.authorLin, W.D.en_US
dc.contributor.authorChao, M.C.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-09T05:56:32Z-
dc.date.available2014-06-09T05:56:32Z-
dc.identifier.issn0951-4198zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/60459-
dc.description.abstractTrimethyamine (TMA) and trimethylamine N-oxide (TMAO) are the most important urine parameters for diagnosing and monitoring trimethylaminuria. A rapid, simple, and specific method based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) was developed to determine the presence of TMA and TMAO in urine samples from patients with trimethylaminuria. Formation of the quaternary tetramethylamino iodide by derivatization of TMA with methyl iodide allows measurement of TMA by MALDI-TOFMS. The method is repeatable and reproducible, with coefficients of variance (CVs) <3%. This new method was used for direct determination of TMA and TMAO in urine specimens obtained from normal children and patients. The proposed method allows for rapid and reliable measurements of TMA and TMAO in urine specimens from patients affected by trimethylaminuria. Copyright (C) 2007 John Wiley & Sons, Ltd.en_US
dc.language.isoen_USzh_TW
dc.relationRapid Communications in Mass Spectrometryen_US
dc.relation.ispartofseriesRapid Communications in Mass Spectrometry, Volume 21, Issue 12, Page(s) 1915-1919.en_US
dc.relation.urihttp://dx.doi.org/10.1002/rcm.3043en_US
dc.subjectamino-acid-analysisen_US
dc.subjectfish-odor syndromeen_US
dc.subjectgas-chromatographyen_US
dc.subjectquantitative-determinationen_US
dc.subjectdiagnosisen_US
dc.titleRapid screening assay of trimethylaminuria in urine with matrix-assisted laser desorption/ionization time-of-flight mass spectrometryen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1002/rcm.3043zh_TW
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:分子生物學研究所
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