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標題: Protective Effects of Anthocyan ins against Amyloid beta-Peptide-Induced Damage in Neuro-2A Cells
作者: Shih, Ping-Hsiao
Wu, Chi-Hao
Yeh, Chi-Tai
Yen, Gow-Chin
關鍵字: Alzheimer's disease;amyloid beta-protein;anthocyanin;beta-secretase;neuroprotection;Neuro-2A cells;alzheimers-disease;a-beta;induced neurotoxicity;cholesterol;activation;pathology;model;secretase;toxicity;pathways
Project: Journal of Agricultural and Food Chemistry, Volume 59, Issue 5, Page(s) 1683-1689.
Alzheimer's disease is neuropathologically characterized by amyloid beta-protein (A beta) deposition, resulting in neurotoxicity. Herein, we focused on the prevention of anthocyanins from amyloid-mediated neurodysfunction. The data demonstrated that combined exposure of A beta(1-40) and A beta(25-35) to Neuro-2A cells resulted in reactive oxygen species (ROS) production and perturbation of calcium homeostasis. The expressions of LXR alpha, ApoE, ABCA1, and seladin-1 genes were significantly clown-regulated upon A beta challenge. beta-Secretase, the rate-limiting enzyme that catalyzes amyloid precursor protein transform to A beta, was up-regulated by A beta treatment. For the duration of A beta stimulation, malvidin (Mal) or oenin (Oen; malvidin-3-O-glucoside) was added, and the protective effects were observed. Mal and Oen showed protective effects against A beta-induced neurotoxicity through blocking ROS formation, preserving Ca(2+) homeostasis, and preventing A beta-mediated perturbation of certain genes involved in A beta metabolism and cellular defense. The present study implicates anthocyanin as a potential therapeutic candidate for the prevention of amyloid-mediated neurodysfunction.
ISSN: 0021-8561
DOI: 10.1021/jf103822h
Appears in Collections:食品暨應用生物科技學系

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