Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/61722
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dc.contributor.authorHsu, Hsing-Wenen_US
dc.contributor.authorWang, Jen-Hsienen_US
dc.contributor.authorLiu, Chaio-Lien_US
dc.contributor.authorChen, Chin-Shuhen_US
dc.contributor.authorWang, Yuan-Chuenen_US
dc.contributor.other國立中興大學食品暨應用生物科技學系zh_TW
dc.contributor.otherNational Chung Hsing University,Department of Food Science and Biotechnologyen_US
dc.date2011-9zh_TW
dc.date.accessioned2014-06-09T06:25:43Z-
dc.date.available2014-06-09T06:25:43Z-
dc.identifier.issn1996-0808zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/61722-
dc.description.abstractEnterovirus 71 (EV71) infection caused host immune responses and resulted in severe pathogenicity. In this study, a preliminary anti-EV71 activity of 58 Taiwanese folk medicinal plants and further investigations of the anti-EV71 activity and immunomodulatory effect of Ampelopsis brevipedunculata (Maxim.) Trautv (ABT) were performed. Of the 58 plant extracts, 37 extracts exhibited anti-EV71 activity and strong activity was demonstrated by six extracts with average 50% inhibitory concentrations (IC(50)) below 80 mu g/ml. The ABT (one of the most effective plants) acetone extract exhibited relatively high anti-EV71 activity with 26.11 mu g/ml of average IC(50), 3.6% of that of the positive control (ribavirin, 734.52 mu g/ml). The anti-EV71 modes of the ABT extract included viral infection prevention, viral inactivation and anti-viral replication. Acidic pH treatments slightly decreased anti-EV71 activity of the extract. The ABT extract significantly increased the interlukin-6 (IL-6) and IL-1 beta and decreased the IL-8 levels in the EV71-infected cells. In summary, a high rate of the screened plants exhibited anti-EV71 activity and the greatest activity was demonstrated by ABT. High amounts of IL-6 induction in the infected-cells had high correlation with the anti-viral replication of the ABT extract.en_US
dc.language.isoen_USzh_TW
dc.relationAfrican Journal of Microbiology Research, Volume 5, Issue 17, Page(s) 2500-2511.en_US
dc.relation.isversionofAfr. J. Microbiol. Res.en_US
dc.subjectAntienterovirus 71 activityen_US
dc.subjectAmpelopsis brevipedunculata (Maxim.)en_US
dc.subjectTrautven_US
dc.subjectimmune modulationen_US
dc.subjectmedicinal planten_US
dc.subjectcentral-nervous-systemen_US
dc.subjectin-vitroen_US
dc.subjectinfectionen_US
dc.subjectinhibitionen_US
dc.subjectextractsen_US
dc.subjectherbsen_US
dc.subjectil-6en_US
dc.subjectl.en_US
dc.subjectinterleukin-6en_US
dc.subjectencephalitisen_US
dc.titleAnti-enterovirus 71 activity screening of Taiwanese folk medicinal plants and immune modulation of Ampelopsis brevipedunculata (Maxim.) Trautv against the virusen_US
dc.typeJournal Articlezh_TW
dc.contributor.catalogerMiao-zhen Luoen_US
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.languageiso639-1en_US-
item.fulltextwith fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:食品暨應用生物科技學系
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