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標題: In Vitro Activity of Paris polyphylla Smith Against Enterovirus 71 and Coxsackievirus B3 and Its Immune Modulation
作者: Wang, Yuan-Chuen
Yi, Tsu-Yi
Lin, Kuei-Hsiang
關鍵字: Paris polyphylla Smith;Enterovirus 71;Coxsackievirus B3;Immune;Modulation;Cytokine;var. yunnanensis;infection;myocarditis;apoptosis;mice;cardiomyopathy;encephalitis;outbreak;saponins;taiwan
Project: American Journal of Chinese Medicine, Volume 39, Issue 6, Page(s) 1219-1234.
Enterovirus 71 (EV71) and coxsackievirus B3 (CVB3) have resulted in severe pathogenesis caused by the host's immune response, including the cytokine cascade. Paris polyphylla Smith is a folk medicinal plant in Asia traditionally prescribed for the reduction of pain and elimination of poisoning. In this study, we investigated the anti-EV71 and CVB3 activity of P. polyphylla Smith as well as its immune modulation. The IC(50) for the P. polyphylla Smith 95% ethanol extract against EV71 and CVB3 were 12.5-23% and 99-156% of that of ribavirin, a positive control. Prevention of viral infection, viral inactivation, and anti-viral replication effects against both EV71 and CVB3 were demonstrated by the extract, the anti-viral replication effect being dominant. The extract significantly increased IL-6 production in both EV71- and CVB3-infected cells. A high correlation was possibly demonstrated between the high amounts of IL-6 induction in the EV71 and CVB3-infected cells and the anti-viral replication activity of the extract. In conclusion, good anti-EV71 and CVB3 activity was observed in the P. polyphylla Smith 95% ethanol extract. The high amounts of IL-6 induction in the virus-infected cells played a key role in the antiviral activity of the extract.
ISSN: 0192-415X
DOI: 10.1142/s0192415x11009512
Appears in Collections:食品暨應用生物科技學系

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