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標題: Lotus (Nelumbo nucifera Gaertn) plumule polysaccharide protects the spleen and liver from spontaneous inflammation in non-obese diabetic mice by modulating pro-/anti-inflammatory cytokine gene expression
作者: Liao, Chun-Huei
Lin, Jin-Yuarn
關鍵字: Lotus plumule polysaccharide;Non-obese diabetic mice;Relative;expression of pro-/anti-inflammatory cytokine genes;Spontaneous;inflammation;Type 1 diabetes;agrocybe-chaxingu polysaccharide;time quantitative pcr;nod mouse;autoimmunity;cell;disease
Project: Food Chemistry, Volume 129, Issue 2, Page(s) 245-252.
A novel lotus plumule polysaccharide (LPPS) was administered to non-obese diabetic (NOD) mice for 15 weeks to evaluate the protective effects of LPPS on type 1 diabetes. After the 15-week feeding experiment, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-10 expressions in the spleen, liver and kidney of the experimental mice were measured using enzyme-linked immunosorbent assay or real-time quantitative polymerase chain reaction assay. The results showed that LPPS significantly (p < 0.05) decreased the absolute weights of the enlarged spleens in the NOD mice in a dose-dependent manner, inhibited pro-inflammatory TNF-alpha and IL-6 cytokine production and decreased the secretion ratio of IL-6/IL-10 in splenocyte cultures. LPPS markedly decreased the relative expression of pro-/anti-inflammatory cytokine genes (TNF-alpha/IL-10 and IL-6/IL-10) in the livers of NOD mice. Our results suggest that LPPS protected the spleen and liver from spontaneous inflammation in NOD mice by modulating pro-/anti-inflammatory cytokine gene expression. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN: 0308-8146
DOI: 10.1016/j.foodchem.2011.03.103
Appears in Collections:食品暨應用生物科技學系

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