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|標題:||Lotus (Nelumbo nucifera Gaertn) plumule polysaccharide protects the spleen and liver from spontaneous inflammation in non-obese diabetic mice by modulating pro-/anti-inflammatory cytokine gene expression||作者:||Liao, Chun-Huei
|關鍵字:||Lotus plumule polysaccharide;Non-obese diabetic mice;Relative;expression of pro-/anti-inflammatory cytokine genes;Spontaneous;inflammation;Type 1 diabetes;agrocybe-chaxingu polysaccharide;time quantitative pcr;nod mouse;autoimmunity;cell;disease||Project:||Food Chemistry, Volume 129, Issue 2, Page(s) 245-252.||摘要:||
A novel lotus plumule polysaccharide (LPPS) was administered to non-obese diabetic (NOD) mice for 15 weeks to evaluate the protective effects of LPPS on type 1 diabetes. After the 15-week feeding experiment, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-10 expressions in the spleen, liver and kidney of the experimental mice were measured using enzyme-linked immunosorbent assay or real-time quantitative polymerase chain reaction assay. The results showed that LPPS significantly (p < 0.05) decreased the absolute weights of the enlarged spleens in the NOD mice in a dose-dependent manner, inhibited pro-inflammatory TNF-alpha and IL-6 cytokine production and decreased the secretion ratio of IL-6/IL-10 in splenocyte cultures. LPPS markedly decreased the relative expression of pro-/anti-inflammatory cytokine genes (TNF-alpha/IL-10 and IL-6/IL-10) in the livers of NOD mice. Our results suggest that LPPS protected the spleen and liver from spontaneous inflammation in NOD mice by modulating pro-/anti-inflammatory cytokine gene expression. (C) 2011 Elsevier Ltd. All rights reserved.
|Appears in Collections:||食品暨應用生物科技學系|
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