Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/61725
DC FieldValueLanguage
dc.contributor.authorLiao, Chun-Hueien_US
dc.contributor.authorLin, Jin-Yuarnen_US
dc.contributor.otherNational Chung Hsing University,Department of Food Science and Biotechnologyen_US
dc.contributor.other國立中興大學食品暨應用生物科技學系zh_TW
dc.date2011-11zh_TW
dc.date.accessioned2014-06-09T06:25:43Z-
dc.date.available2014-06-09T06:25:43Z-
dc.identifier.issn0308-8146zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/61725-
dc.description.abstractA novel lotus plumule polysaccharide (LPPS) was administered to non-obese diabetic (NOD) mice for 15 weeks to evaluate the protective effects of LPPS on type 1 diabetes. After the 15-week feeding experiment, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-10 expressions in the spleen, liver and kidney of the experimental mice were measured using enzyme-linked immunosorbent assay or real-time quantitative polymerase chain reaction assay. The results showed that LPPS significantly (p < 0.05) decreased the absolute weights of the enlarged spleens in the NOD mice in a dose-dependent manner, inhibited pro-inflammatory TNF-alpha and IL-6 cytokine production and decreased the secretion ratio of IL-6/IL-10 in splenocyte cultures. LPPS markedly decreased the relative expression of pro-/anti-inflammatory cytokine genes (TNF-alpha/IL-10 and IL-6/IL-10) in the livers of NOD mice. Our results suggest that LPPS protected the spleen and liver from spontaneous inflammation in NOD mice by modulating pro-/anti-inflammatory cytokine gene expression. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationFood Chemistry, Volume 129, Issue 2, Page(s) 245-252.en_US
dc.subjectLotus plumule polysaccharideen_US
dc.subjectNon-obese diabetic miceen_US
dc.subjectRelativeen_US
dc.subjectexpression of pro-/anti-inflammatory cytokine genesen_US
dc.subjectSpontaneousen_US
dc.subjectinflammationen_US
dc.subjectType 1 diabetesen_US
dc.subjectagrocybe-chaxingu polysaccharideen_US
dc.subjecttime quantitative pcren_US
dc.subjectnod mouseen_US
dc.subjectautoimmunityen_US
dc.subjectcellen_US
dc.subjectdiseaseen_US
dc.titleLotus (Nelumbo nucifera Gaertn) plumule polysaccharide protects the spleen and liver from spontaneous inflammation in non-obese diabetic mice by modulating pro-/anti-inflammatory cytokine gene expressionen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.foodchem.2011.03.103zh_TW
dc.contributor.catalogerMiao-zhen Luoen_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextno fulltext-
item.languageiso639-1en_US-
item.grantfulltextnone-
Appears in Collections:食品暨應用生物科技學系
Show simple item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.