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|標題:||Characterisation of the chemical composition and in vitro anti-inflammation assessment of a novel lotus (Nelumbo nucifera Gaertn) plumule polysaccharide||作者:||Liao, Chun-Huei
|關鍵字:||Anti-inflammatory activity;Non-obese diabetes (NOD) mice;Lotus plumule;polysaccharide (LPPS);Type 1 diabetes;polymyxin-b;immune dysregulation;water extract;nod mice;mouse;model;lipopolysaccharide;supplementation;responses||Project:||Food Chemistry, Volume 125, Issue 3, Page(s) 930-935.||摘要:||
Lotus plumule has been recognised as an anti-inflammatory agent. A novel lotus plumule polysaccharide (LPPS) was prepared, characterised and cultured with splenocytes from non-obese diabetes (NOD) and BALB/c mice (as a control) to further evaluate its anti-inflammatory effects in this study. The results showed the molecular weights of LPPS respectively distributed at 391 kDa (89.8 +/- 0.5%) and 5 kDa (10.1 +/- 1.5%) using HPLC analysis. The neutral sugar composition in LPPS comprised xylose (33.4 +/- 10.0%), glucose (25.7 +/- 1.6%), fructose (22.0 +/- 15.0%), galactose (10.5 +/- 3.3%), and fucose (8.1 +/- 3.5%). LPPS administrations at appropriate concentrations significantly (P<0.05) increased interleukin (IL)-10, IL-6, tumour necrosis factor (TNF)-alpha secretions by splenocytes from both NOD and BALB/c mice at ages of 15, 22 and 26 weeks, respectively. However, LPPS administrations markedly (P<0.05) increased secretion ratios of anti-/pro-inflammatory (IL-10/IL-6) cytokines by splenocytes. The present study suggests that LPPS may have potential to treat type 1 diabetes via its potent anti-inflammatory activity. (C) 2010 Elsevier Ltd. All rights reserved.
|Appears in Collections:||食品暨應用生物科技學系|
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