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標題: Amaranthus spinosus L. inhibits spontaneous and dexamethasone-induced apoptosis in murine primary splenocytes
作者: Lin, J.Y.
Li, C.Y.
Lin, B.F.
關鍵字: murine primary splenocytes;wild Amaranthus spinosus water extract;(WASWE);anti-apoptosis;DNA fragmentation;medicinal vegetables;activated-charcoal;oxidative stress;caffeic acid;cells;adsorption;expression;mice;hepatotoxicity;proliferation;antioxidant
Project: Journal of Food and Drug Analysis
期刊/報告no:: Journal of Food and Drug Analysis, Volume 16, Issue 4, Page(s) 52-61.
Amaranthus spinosus L. (thorny amaranth) is traditionally selected to be an anti-diabetic herb in Taiwan. This study assessed the immuno-modulatory effects of wild A. spinosus water extract (WASWE) on spontaneous and dexamethasone (DEX)-induced apoptosis in murine primary splenocytes. The Cultured splenocytes treated with WASWE products were harvested and analyzed to assess their apoptotic status according to DNA fragmentation by flow cytometry and agarose gel electrophoresis. The results showed WASWE inhibited the spontaneous and DEX-induced apoptosis of splenocytes. Furthermore. both WASWE and its activated charcoal-treated sample administered at concentration of 1.250 mg/mL inhibited intracellular protein levels of p53 (an apoptotic inducer protein) and p80 (a form Of tumor necrosis factor (TNF) receptor), which are involved in apoptosis. The present Study suggested the existence of a heal-labile anti-apoptotic component with high Molecular weight in WASWE.
ISSN: 1021-9498
Appears in Collections:食品暨應用生物科技學系

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