Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/61996
DC FieldValueLanguage
dc.contributor.authorYang, C.M.en_US
dc.contributor.author胡淼琳zh_TW
dc.contributor.authorZhou, Y.J.en_US
dc.contributor.authorWang, R.J.en_US
dc.contributor.authorHu, M.L.en_US
dc.date2009zh_TW
dc.date.accessioned2014-06-09T06:26:13Z-
dc.date.available2014-06-09T06:26:13Z-
dc.identifier.issn0378-8741zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/61996-
dc.description.abstractEthnopharmacological relevance: Antrodia cinnamomea is a popular medicinal mushroom in Taiwan that has been widely used for treatment of various cancers and liver diseases. Aim of the study:This study aimed to investigate the immunomodulatory effect on angiogenesis of polysaccharides from mycelia of Antrodia cinnamomea (PMAC). Materials and methods: PMAC were extracted in boiling water, precipitated with 95% ethanol, and separated into four different molecular weights (<5, 5-30, 30-100, >100 kDa). Tube formation and chorioallantoic membrane (CAM) assay were used to determine the in vitro and ex vivo anti-angiogenic effects. Results: Only the PMAC-mononuclear cells (MNCs)-conditioned medium (CM) with MW > 100 kDa significantly and concentration-dependently decreased the secretion of vascular endothelial growth factor in human leukemia cells and inhibited the matrigel tube formation in human umbilical vein endothelial cells. Similarly only the PMAC-MNC-CM with MW > 100 kDa significantly and concentration-dependently increased the levels of interleukin (IL)-12 and interferon-gamma (IFN-gamma). In addition, the ex vivo CAM assay revealed that only the PMAC with MW > 100 kDa significantly and dose-dependently inhibited neovascularization. Conclusions: PMAC with MW > 100 kDa are anti-angiogenic in vitro and ex vivo, and the effects are likely through immunomodulation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Ethnopharmacologyen_US
dc.relation.ispartofseriesJournal of Ethnopharmacology, Volume 123, Issue 3, Page(s) 407-412.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.jep.2009.03.034en_US
dc.subjectAngiogenesisen_US
dc.subjectAntrodia cinnamomeaen_US
dc.subjectImmunomodulationen_US
dc.subjectPolysaccharidesen_US
dc.subjectVascular endothelial growth factoren_US
dc.subjectreishi polysaccharidesen_US
dc.subjectinterleukin-12en_US
dc.subjectcamphorataen_US
dc.subjectmushroomsen_US
dc.subjectantitumoren_US
dc.subjectcellsen_US
dc.subjectextracten_US
dc.subjecttumorsen_US
dc.titleAnti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weightsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.jep.2009.03.034zh_TW
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
Appears in Collections:食品暨應用生物科技學系
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