Please use this identifier to cite or link to this item:
標題: Antiproliferative and antimetastatic effects of the ethanolic extract of Phellinus igniarius (Linnearus : Fries) Quelet
作者: Song, T.Y.
Lin, H.C.
Yang, N.C.
Hu, M.L.
關鍵字: antiproliferation;antimetastasis;Phellinus igniarius;synergy;oxaliplatin;5-flurouracil;endothelial growth-factor;cells in-vitro;hepatocellular-carcinoma;caffeic acid;cancer-cells;angiogenesis;metastasis;expression;flavonoids;permeability
Project: Journal of Ethnopharmacology
期刊/報告no:: Journal of Ethnopharmacology, Volume 115, Issue 1, Page(s) 50-56.
Aim of this study: Phellinus igniarius (Linnearus: Fries) Quelet (Phellinus igniarius) has been used in oriental countries for treatment of various diseases including cancer. However, it is unclear how Phellinus igniarius exerts anticancer effects. Materials and methods: In this study the ethanolic extract from the fruiting body of Phellinus igniarius (EEPI) was used to evaluate the antiproliferative and antimetastatic effects in human hepatocarcinoma SK-Hep-1 cells and rat heart vascular endothelial cells (RHE cells). Results: We found that EEPI inhibited the proliferation of both cell lines in a dose-dependent manner, and the IC50 values at 48 h were 72 and 103 mu g/ml for SK-Hep-1 cells and RHE cells, respectively. EEPI at non- or sub-cytotoxic concentrations (25-100 mu g/ml) markedly inhibited the migration and invasion of SK-Hep-1 cells. EEPI added at 25 mu g/ml significantly decreased the secretion of matrix metalloproteinase-2 (MMP-2) (49%, p < 0.01) and vascular endothelial growth factor (VEGF) (13%, p < 0.05) in SK-Hep-1 cells. EEPI at 25 mu g/ml completely inhibited matrigel-induced tube formation in RHE cells. Importantly, EEPI (25 or 50 mu g/ml) in combination with oxaliplatin (Oxa) or 5-flurouracil (5-FU) synergistically inhibited the proliferation of SK-Hep-1 cells. Conclusion: These results demonstrate the antiproliferative and antimetastatic effects of EEPI in vitro and the potential of EEPI as an adjuvant for chemotherapy. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
ISSN: 0378-8741
DOI: 10.1016/j.jep.2007.09.001
Appears in Collections:食品暨應用生物科技學系

Show full item record

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.